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376            PART 6  ■  Neoplastic Disorders




                                                         k  m   . DS                                                            A                 RNA        DNA

                                           ALL                  m      k                       k  m                                  m     m                  . S  m                                               -

               (AMKL). DS                                                 m               -                                               ,            EBV                              m            ,

                                    (  MD),             k  m       m     AMKL.                                                                                         B   k   ’     m      m

                    T                                    k  m                             D      ’                                   m  ,                 .

                         m                             m                                                                        V                                                                                  ,

                                        m                         m                m          -                                                     m      m                     . C

                         .   MD        DS-AMKL                 m                                                                                                            m                  m                    -

                  q                    m                  x                  X-    k     GA  A                                                                   .

                      ,                                GA  A                                . T

               m                            x                                                                              Epstein-Barr Virus

               (GA  A   )                                             m               GA  A                                T                         DNA-            EBV        B   k   ’     m      m

               m                                      m                          m         .                                                            z         k

                    C                   DS              m    m        k                   ALL                                 m     m                         . B   k   ’     m     m

                                                                                                 . T                             -                z              m                               q             A

                                              m      k                     k  m             -                                                           q                         . I                 m          ,

                                                               .   MD,                                  -                              E                       U         S       ,

                       z           mm         m     k                                                                                 %         %           B   k   ’             m                 m      -

                                        ,                  %         %                      D      ’                       m                                                    EBV. Am

                         m  . M                    MD                                       ,                                  W                        , EBV                                                      -

                                                     k  m              m  . A       x m             %                      m                                           m                    .

                                         MD              AMKL                      .
                                                                                                                           Hum an T-Cell Leukem ia Viruses

               Genetic Abnorm alities                                                                                      T         m  m                H  LV    m                    (H  LV-I)


               T   m         mm                                               CML                                                                           .  S                              ,               m

                  m                    ALL    k                   P                          m  -                           m                    m                                                           m

                  m  ,                                    DNA (                    )                                                                                                                    m

                     m     m                  ,                          (  ;    ). I                                       -            k  m           m      m  . H  LV                RNA    m

                            %         %                   k  m            . O      ,           m-                                 (              ) k                               m     .

               m                                                               m     m                                          H  LV-I                                                                    m

                 ,                          ( ;  ),                 ,                          ( ;  ).                                                    m                    -                            k

                    O              m     m                             deletions        inver-                                         m     . C                                U         S       ,

               sions (                     m                DNA                                -                                             . HIV                                              q          mm  -

               m     m  )                 mm    .                                                                                                       m   (AIDS). T

                                                                                                                                                                     H  LV-I        H  LV-II                -

               Viral Agents                                                                                                      z                                                      z                       -

                                                                                                                                                 mm                    .
               C                                 ,        x  m     , E         -B             (EBV),                            HIV                                                . R

               m                                        m                     (“m      ”)                                             ,             -              RNA                                z  m  ,

               U         S       . I   A       ,                                  k         B   k   ’                                                             ,                        RNA        DNA.

                  m      m  ,                           m                  m                    k  m   .                   T                              m

               I                               m       -          m      m  /     k  m           -                         DNA                         RNA—          ,           m               .

               (H  LV-  )                                          -                    m

                    k  m   . M                            J                      C                      .                  Secondary Causes of Leukemias

               T                            mm               U         S       .

                                                                                                                           C
               Viral Characteristics                                                                                            m                                                k


               T                                                    m      m                                                        ,             AML,                 . D                      k

                               (    ,         m                          x           )                                              ,          x  m     ,                       m                         m        ,

                                    m       mm                                  (HIV).  O                                                                  x    ,       x m     ,                           -

                                                                                                                                    ,                      k                        k         k  m   . T

                           m                      ,                      k  m              m      -                             k  m                                                                         m

               m   . T                                                       m                                                                  f                  .

                               :                                                                                                S                 AML m                                   :


                 .  T                         q         ,                   EBV                                            ■    W              m                             (  .  .,

                .  T                                                                                        ,                                    )

                            x  m     , HIV                                                                                 ■    W                                     (  .  ., F           ’        m   )
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