Page 388 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

372 PART 6 ■ Neoplastic Disorders

m m / ,
COMPARISON OF LEUKEMIAS,

LYMPHOMAS, AND MYELOMAS k . C k m
m m , m m m

Leukemia, lymphomas, myelomas - m / , -

, neoplasms. k m x m

T m m m . T

m . V m m k m , m

m , m , -

, m , m , m . m m m

L k m , k , .

m . L m m m m - C m MDS MPN .

m m, m m

. T m m m H k ’ m- Note: This is a good time to review the de nitions of Key

m -H k ’ m m . M m m Terms found in the Glossary and ash cards on

m . I m m , , and also a good time to complete Review Questions related

m m m m to the preceding content.

( . ).

FORMS OF LEUKEMIA

CLASSIFICA IONS OF LEUKEMIAS

T m m k m m

H , V z - A V k m

k m . H m , m -

m k m k m m

m , k , lymph- m m -

adenopathy. V k m .

, m . N , m mm -

m m - k m . T French-American-British (FAB) -

k m m m x . k m m

T m m , m , m - World Health Organization (WHO) classi ca-

k m k m tion m. T FAB m m .

acute chronic. A k m - T WHO m m m

z m m , m mm .

TABLE 20.1 Comparative Features of Leukemias and Lymphomas

Leukemias Lymphomas Myelomas

Basic characteristic Overproduction of various Solid malignant tumors of the lymph Overproduction of

types of immature or mature nodes plasma cells in the

leukocytes in the bone mar- bone marrow with

row and/or peripheral blood, concurrent production

in most types of leukemias of abnormal proteins

Cell type Usually involves leukocytes Lymphocyte is the distinctive cell type. Plasma cells

of the myelogenous or lym- Reed-Sternberg cells are diagnostic of

phocytic cell types Hodgkin’s-type lymphoma.

Site of malignant cells Malignant cells freely tres- Malignant cells are initially con ned Plasma cells form a

pass the blood-brain barrier to the organs containing mononuclear mass or tumor that is

phagocyte cells such as the lymph nodes, located in the bone

spleen, liver, and bone marrow. marrow.

Notes Lymphomas can spill over into the

circulating blood and present a leukemic-

appearing picture on a peripheral blood

smear.