Page 390 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

374 PART 6 ■ Neoplastic Disorders

■ ranslocations m mm DNA Oncogenes Formed by Somatic
k m . A m TABLE 20.3 Mutation of Normal Genetic Loci

m m k m

m m . T k Oncogene Disorder

— x m ,

m Abl Chronic myelogenous leukemia

m . Myc Burkitt’s lymphoma

■ Deletions m m . T Ras type Variety of tumors
m k

k, x m , m .

■ Inversions m m q
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( ) . B

. m ,

■ Addition m x m m x x
m m . T m m m .

. T m T k -

m . . O m

m m x
E m ,

m m k DNA m m . m m m . T , -
C DNA m m . I

m . F x m , m , m m
FL , -KI , RAS m . O

mm m k m (AML ). m , m x -
. O x m

% % m m
Oncogenes
m m
A oncogene m . M , m

f - m ,

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Tum or-Suppressing Genes
. T m x -

m z m A

m m . . T tumor-suppressing genes -

. S m m ’ m . W

m DNA. , k

. P m mm m’ m m ,

z m . m -

. S m m . T , m -

m m

. m m
.
R - T m m -

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M . C . N m -

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z , m DNA m m

. T m m - - mm

m m m . m . Ex m

Protooncogenes . β-I

. m
Protooncogenes m

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k . T m m m . I m