Page 391 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )
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CHAPTER 20  ■  Characteristics of Leukemias, Lymphomas, and Myelomas                                          375




                                                                                                            -                                               Occupations Related to a Higher-

                                                                -                         ,                                        TABLE         20.4       Than-Average Risk of Malignancy

                                                                                                                                                            in Hematologically Related Sites

                                                          m                              . G        m

                                                                                                                                   Occupation                                    Site

                                                                          . I                            m

                                                                                                               -                   Chemist                                       Lymphatic system

                           m                                             m     m         ,                                         Radiologist                                   Bone marrow

                   m                                         m                 m                                                   Rubber industry worker                        Blood

                                                                               k                                  .

                        A   m       x      m                                 m                           -                         Woodworker                                    Lymphatic system

                                        ,

                                                                                         . S  m              -                                   m                ,                      k  m   . B    z

                                                       m                                                                                                                                       ,       m                ,

                      m                                           m                            m                                        m                    ,                       -                           .  I

                          m                     . T       m                                  m   -     -                                                             m  k  ,    m           ,                       -

                                         m               m                                                                          ,                 ,                  ,                            . C    m

                      m                                             .
                                                                                                                                x             m                      k                                k


                   Im m unological Surveillance                                                                                m                        k  m    (AML)                          m

                   Imm                                  mm                            m                                             k  m    (ALL). T                                                j    -


                                                       m               . A                              -                                                           -       -                 k     m
                                   x                  x           x                                  m                                   m                        m                                         .  .


                                             mm          j                      ,                                                   P                                                m
                                                                             m                       mm                         mm                     ,          x  m     ,                                          ,


                                . T                            m             m    m            m                                                               k                             ,              m     m
                                                      m           m                                                                  ALL.


                                          m                                               m  .                                      A                      k                            k  m                          m-
                                                                                                                                               m                                                           m


                   Occupational Exposure                                                                                        m           m                                    m-             m
                                                                                                                                    m            . T                     k                                    m  -

                   I     z                               x  m                                                     -                                                m      m

                                                                            k m   . H              ,                                      .

                   M      m   C                                  , I       ,

                       m               -                   k  m   . T                      H        m                          Genetic Abnormalities and Associations

                                                  –                                                             -

                   k  m   . B                                          m           ,                                           C                            m                                                    m

                                               k  m           m    m          q                                                                      k  m   . S                                                        -

                                                . T                                      m      m         -                    k  m                                    ,

                                k m         m        q                                              .                                              k  m                 m     ,
                                                                                                                                       . M                                                  k   m

                   Environmental Exposure                                                                                              m                          k  m                                     m

                                                                                                                                                                                       m  . S
                   T                   k           k  m        m   x                             -                                        k  m                                                         (

                                        ,         x  m     ,                           , x-      ,                               m         m   )                      k  m   ,                            k         .

                   C           ,                                . Ex                                      -                         T       k                                                 m                      -

                                                m                          m      m                                            k  m                                      m              m       m

                                      k          k  m   ,               x                    k                                     m              ,                                                      m      m

                                       k               m    .                                                                                   ,     q        ,               -               mm

                        Ex                                                             k                                                                                           m     mm       m            m

                                  k  m   .  J                    m         m                                                                             m                                  m                 k

                                                  k                                       k  m   ,                                       .

                                                         x          .

                                                                                                                               Dow n’s Syndrom e
                   Chemical and Drug Exposure
                                                                                                                               D      ’             m    (DS)             m          mm          m

                   O                      x                     m                                                                aneuploidy. C                   DS,                                 m       ,

                                                                        k  m   . P                 x                                                   m                           m       ,      mm             m-


                                   m             z          k                                                                                 m                 ,          m                          ,
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