Page 389 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 20 ■ Characteristics of Leukemias, Lymphomas, and Myelomas 373

French-American-British Classi cation m ). S m q m

U FAB m, k m .

k :

■ M FAC ORS RELA ED O HE

■ M OCCURRENCE OF LEUKEMIA

■ L m

W m L k m q

m , m j - m m m m m -

k k m . I k m

k , x m , m - x -

, m , m - m . L k m m

m , m k m (CLL). - , m m

M mm m k k m m -

( m ), , . m m .

O m k A m j k m

, j m , m m -

k , x . k m m m (
. ). T

World Health Organization Classi cation . G mm

. O x
T ( ) WHO -

m m : m , m- . E m x

, / . C . C m x

m m m mm - . G m

, . V

m , m m . . S

P m , x m , m k -

m , m m m / k m , k m NOTE: This is a good time to complete Review Questions for

m , m related preceding content.

m , m m m -

m , x m , m m , m -

/m m , m Genetic and Immunological Factors

m , m ( ) B- /NK m , M m k m ;

H k ’ m m , / m . m m m mm .

T m m m S m m m :

. W m

m m ,

, m x ,

. Potential Predisposing Factors
TABLE 20.2 for the Development of

Leukemias and Lymphomas
PROGNOSIS AND REA MEN

Benzene, Hydrocarbons, and
U k m m m m . Chemicals Hair Dyes

R

. T , - Environmental Ionizing radiation, insecticides,

, herbicides, and fungicides

. Drugs Alkylating agents and chloramphenicol

M , , m Viruses Herpesvirus (EBV)

m m

m m k m Human immunode ciency virus (HIV)

m m . I , m Human T-cell leukemia virus (HTLV-I)

m , Genetic Down’s syndrome

x m , m k m (CML). E syndromes Fanconi’s anemia

m q m m

m . T m m m Hematologic Myelodysplastic syndromes

( C conditions