Page 189 - Textbook of Pathology, 6th Edition

SMOOTH MUSCLE. Non-striated muscle has limited margins, migration, multilayering and differentiation of 173
regenerative capacity e.g. appearance of smooth muscle in epithelial cells in the same way as in the epidermal cells in
the arterioles in granulation tissue. However, in large healing of skin wounds.
destructive lesions, the smooth muscle is replaced by
permanent scar tissue. Healing of Solid Epithelial Organs

CARDIAC MUSCLE. Destruction of heart muscle is replaced Following gross tissue damage to organs like the kidney, liver CHAPTER 6
by fibrous tissue. However, in situations where the and thyroid, the replacement is by fibrous scar e.g. in chronic
endomysium of individual cardiac fibre is intact (e.g. in pyelonephritis and cirrhosis of liver. However, in
diphtheria and coxsackie virus infections), regeneration of parenchymal cell damage with intact basement membrane
cardiac fibres may occur in young patients. or intact supporting stromal tissue, regeneration may occur.
For example:
In tubular necrosis of kidney with intact basement
Healing of Mucosal Surfaces
membrane, proliferation and slow migration of tubular
The cells of mucosal surfaces have very good regeneration epithelial cells may occur to form renal tubules.
and are normally being lost and replaced continuously e.g. In viral hepatitis, if part of the liver lobule is damaged with
mucosa of alimentary tract, respiratory tract, urinary tract, intact stromal network, proliferation of hepatocytes may
uterine endometrium etc. This occurs by proliferation from result in restoration of liver lobule. Inflammation and Healing

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