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RepRoductive  ` REPRODUCTIVE—PATHOlOgy               RepRoductive  ` REPRODUCTIVE—PATHOlOgy           SectioN iii      641




                  Pregnancy complications (continued)
                   Vasa previa           Fetal vessels run over, or in close proximity
                                          to, cervical os. May result in vessel rupture,             Umbilical
                                          exsanguination, fetal death. Presents with                 cord
                                          triad of membrane rupture, painless vaginal
                                          bleeding, fetal bradycardia (< 110 beats/min).
                                          Emergency C-section usually indicated.   Placenta        Placenta            Placenta
                                                                                                   (succenturiate
                                          Frequently associated with velamentous                   lobe)
                                          umbilical cord insertion (cord inserts in                 Velamentous
                                                                                                    attachment
                                          chorioamniotic membrane rather than                       Vasa previa
                                          placenta Ž fetal vessels travel to placenta
                                          unprotected by Wharton jelly).
                   Postpartum            Due to 4 T’s: Tone (uterine atony; most
                    hemorrhage            common), Trauma (lacerations, incisions,
                                          uterine rupture), Thrombin (coagulopathy),
                                          Tissue (retained products of conception).
                                         Treatment: uterine massage, oxytocin. If
                                          refractory, surgical ligation of uterine or
                                          internal iliac artery (will preserve fertility since
                                          ovarian arteries provide collateral circulation).
                   Ectopic pregnancy     Implantation of fertilized ovum in a site other                   Isthmus (highest risk
                                          than the uterus, most often in ampulla of   Fallopian tube  Interstitium  of tubal rupture)
                    A
                                          fallopian tube  A . Suspect with history of
                                          amenorrhea, lower-than-expected rise in hCG                              Ampulla
                                                                                                                    (most
                                          based on dates, and sudden lower abdominal            Uterus           common site)
                                          pain; confirm with ultrasound, which may   Ovary
                                          show extraovarian adnexal mass. Often                                 Infundibulum
                                          clinically mistaken for appendicitis.                             Fimbriae
                                         Pain +/− bleeding.
                                         Risk factors:
                                             ƒ Prior ectopic pregnancy              Normal pregnancy        Ectopic pregnancy
                                             ƒ History of infertility
                                             ƒ Salpingitis (PID)
                                             ƒ Ruptured appendix
                                             ƒ Prior tubal surgery
                                             ƒ Smoking
                                             ƒ Advanced maternal age



                  Amniotic fluid abnormalities
                   Polyhydramnios        Too much amniotic fluid. Often idiopathic, but associated with fetal malformations (eg,
                                          esophageal/duodenal atresia, anencephaly; both result in inability to swallow amniotic fluid),
                                          maternal diabetes, fetal anemia, multiple gestations.
                   Oligohydramnios       Too little amniotic fluid. Associated with placental insufficiency, bilateral renal agenesis, posterior
                                          urethral valves (in males) and resultant inability to excrete urine. Any profound oligohydramnios
                                          can cause Potter sequence.















          FAS1_2019_15-Repro.indd   641                                                                                 11/7/19   5:52 PM
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