Page 751 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

Rapid Review ` Key assoCiations Rapid Review ` equation review SeCTiON iii 707

Disease/FinDinG most Common/imPortant assoCiations PaGe
Pulmonary hypertension Idiopathic, heritable, left heart disease (eg, HF), lung 679
disease (eg, COPD), hypoxemic vasoconstriction (eg,
OSA), thromboembolic (eg, PE)
Hypercoagulability, endothelial damage, blood stasis Virchow triad ( risk of thrombosis) 671
SIADH Small cell carcinoma of the lung 684

` equation review

toPiC equation PaGe
Volume of distribution amount of drug in the body 231
V = plasma drug concentration
d

Half-life 0.7 × V 231
t = CL d
½
Drug clearance rate of elimination of drug 231
CL = = V × K (elimination constant)
plasma drug concentration d e
Loading dose C × V 231
LD = p d
F
Maintenance dose C × CL × τ 231
p
MD =
F
Sensitivity Sensitivity = TP / (TP + FN) 257
Specificity Specificity = TN / (TN + FP) 257
Positive predictive value PPV = TP / (TP + FP) 257

Negative predictive value NPV = TN / (FN + TN) 257
Odds ratio (for case-control studies) a/c ad 258
OR = =
b/d bc
Relative risk a/(a + b) 258
RR =
c/(c + d)
Attributable risk a c 258
AR = −
a + b c + d
Relative risk reduction RRR = 1 − RR 258
Absolute risk reduction c a 258
ARR =
c + d a + b
Number needed to treat NNT = 1/ARR 258
Number needed to harm NNH = 1/AR 258
Cardiac output rate of O consumption 285
CO = 2
(arterial O content − venous O content)
2
2
285
CO = stroke volume × heart rate

FAS1_2019_17_Rapid Rev.indd 707 11/7/19 6:09 PM