Page 749 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

Rapid Review ` Key assoCiations Rapid Review ` Key assoCiations SeCTiON iii 705

Disease/FinDinG most Common/imPortant assoCiations PaGe
Hereditary harmless jaundice Gilbert syndrome (benign congenital unconjugated 394
hyperbilirubinemia)
Hemochromatosis Multiple blood transfusions or hereditary HFE mutation 395
(can result in heart failure, “bronze diabetes,” and  risk
of hepatocellular carcinoma)
Pancreatitis (acute) Gallstones, alcohol 397
Pancreatitis (chronic) Alcohol (adults), cystic fibrosis (kids) 397

Microcytic anemia Iron deficiency 418
Autosplenectomy (fibrosis and shrinkage) Sickle cell disease (hemoglobin S) 422
Bleeding disorder with GpIb deficiency Bernard-Soulier syndrome (defect in platelet adhesion to 427
von Willebrand factor)
Hereditary bleeding disorder von Willebrand disease 428
DIC Severe sepsis, obstetric complications, cancer, burns, 428
trauma, major surgery, acute pancreatitis, APL
Malignancy associated with noninfectious fever Hodgkin lymphoma 429
Type of Hodgkin lymphoma Nodular sclerosis (vs mixed cellularity, lymphocytic 429
predominance, lymphocytic depletion)
t(14;18) Follicular lymphomas (BCL-2 activation, anti-apoptotic 430
oncogene)
t(8;14) Burkitt lymphoma (c-myc fusion, transcription factor 430
oncogene)
Type of non-Hodgkin lymphoma Diffuse large B-cell lymphoma 430
1° bone tumor (adults) Multiple myeloma 431
Age ranges for patient with ALL/CLL/AML/CML ALL: child, CLL: adult > 60, AML: adult ∼ 65, CML: 432,
adult 45–85 433
Malignancy (kids) Leukemia, brain tumors 432,
526
Death in CML Blast crisis 433
t(9;22) Philadelphia chromosome, CML (BCR-ABL oncogene, 434
tyrosine kinase activation), more rarely associated with
ALL
Vertebral compression fracture Osteoporosis (type I: postmenopausal woman; type II: 462
elderly man or woman)
HLA-B27 Psoriatic arthritis, ankylosing spondylitis, IBD-associated 469
arthritis, reactive arthritis (formerly Reiter syndrome)
Death in SLE Lupus nephropathy 470
Tumor of infancy Strawberry hemangioma (grows rapidly and regresses 478
spontaneously by childhood)
Actinic (solar) keratosis Precursor to squamous cell carcinoma 482
Cerebellar tonsillar herniation Chiari I malformation 492
Atrophy of the mammillary bodies Wernicke encephalopathy (thiamine deficiency causing 511
ataxia, ophthalmoplegia, and confusion)

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