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758                       INDEX                                                                                                                                                                             INDEX




               California encephalitis, 167  Carbidopa, 549         Cardiogenic shock, 310      muscular dystrophy, 61
               Calluses (dermatology), 475  Carbohydrate absorption, 373  etiology, 310         rubella, 182
               cAMP (cyclic adenosine    Carbohydrate metabolism    Cardiomegaly                sorbitol, 81
                     monophosphate)        inborn errors of, 80       Pompe disease, 87       Catecholamines
                endocrine hormone messenger,   Carbol fuchsin, 125  Cardiomyopathy, 308         adrenal medulla secretion, 327
                     337                 Carbon dioxide (CO )         β-blockers, 245           amphetamines and, 242
                                                       2
                fructose bisphosphatase-2 and, 76  production in tissues, 127  Chagas disease, 158  contractility effects of, 284
                heat-labile/heat-stable toxin effects,   retention, 679  drug reaction and, 248  ephedrine and, 242
                     132                   transport, 670             familial amyloid, 212     heart contractility, 284
                hyperparathyroidism, 345  Carbonic anhydrase, 670     glycogen storage diseases, 87  pacemaker action potential, 292
                PTH effect on, 332       Carbon monoxide (CO)         heart failure with, 309   pheochromocytoma and, 350
                Vibrio cholerae, 146       vs cyanide poisoning, 667  hemochromatosis and, 395  Catecholamine synthesis
               CAMP factor, 137            electron transport inhibition, 78  hypertrophic, 245  tyrosine catabolism, 83
               Campylobacter spp           poisoning, 666             Kussmaul sign in, 316   Cats (disease vectors)
                animal transmission, 149   teratogenicity, 614        Starling curves, 285      Campylobacter jejuni, 145
                bloody diarrhea, 179       toxicity treatment, 248    sudden cardiac death, 304  Cat scratch disease, 149
                jejuni, 145              Carbon tetrachloride       Cardiotoxicity              Pasteurella multocida, 149, 186
                reactive arthritis and, 469  free radical injury and, 210  doxorubicin, 439     Tinea corporis, 152
               Canagliflozin, 353        Carboplatin                  drugs causing, 444        Toxoplasma gondii, 156, 182
               Canalicular stage (development), 660  mechanism and clinical use, 442  methylxanthines, 687  Cauda equina, 507
               Cancer                      toxicities of, 444         TCA adverse effects, 575  Cauda equina syndrome, 530
                common metastases, 223   Carboplatin toxicity, 444    trastuzumab, 443        Caudal fold closure defects, 358
                deaths from, 272         Carboxylases, 73           Cardiovascular drugs      Caudal regression syndrome, 614
                ESR in, 214              Carboxypeptidase, 373        naming conventions for, 253  Caudate
                hallmarks of, 221        Carcinoembryonic antigen (CEA)   reactions to, 248     basal ganglia, 500
                immune evasion in, 221          (tumor marker), 226  Cardiovascular system, 281–323  Huntington disease, 520
                mortality of, 222        Carcinogens, 225             anatomy, 283            Cavernous hemangiomas
                pneumoconioses, 676, 677   griseofulvin, 200          embryology, 281–283       liver, 392
               Cancer drugs              Carcinoid syndrome, 352      pathology, 298–313      Cavernous hemangiomas (liver), 392
                cell cycle, 438            bronchial carcinoid tumors, 684  pharmacology, 316–322  Cavernous sinus, 542
                targets, 438               somatostatin in treatment, 371  physiology, 284–299  dural venous sinuses, 503
               Cancer epidemiology, 222  Carcinoid tumors             sclerosis of, 473         syndrome, 542
               Candesartan, 610            biomarkers for, 226      Carditis                    thrombosis with mucormycosis,
               Candida albicans, 153       immunohistochemical stains for,   Lyme disease, 146       153
                HIV-positive adults, 177        227                   rheumatic fever, 312    CCR5 protein
                T cell dysfunction, 116    octreotide for, 400      Carfilzomib, 443            HIV and, 175
               Candida spp                 stomach, 379             Carina (trachea), 663       maraviroc, 203
                amphotericin B, 199      Carcinoma in situ, 219     Carmustine, 441             viral receptor, 166
                azoles, 199                cervical dysplasia, 645    pulmonary fibrosis, 251  CD4+ cell count
                echinocandins, 200         ductal, 650              Carnitine acyltransferase I, 73, 89  disease associations by levels, 177
                immunodeficiency infections, 118  neoplastic progression, 219  Carotid artery  CD4 protein, 101
                osteomyelitis, 180         penis, 651                 atherosclerosis in, 302   viral receptor, 166
                tricuspid valve endocarditis and,   vulvar, 644       cavernous sinus, 542    CD4+ T cells (HIV), 176
                     311                 Carcinomas                   emboli from, 538        CD5 protein, 432
                vulvovaginitis, 181        bone, 464                  embryonic development, 619  CD8 protein, 101
               Candidiasis                 colorectal, 388            giant cell arteritis and, 314  CD16 protein, 101
                Candida albicans, 153      invasive, 219            Carotid massage, 296      CD20 protein, 110
                chronic mucocutaneous, 116  metastases of, 219, 223  Carotid sinus, 296         in CLL, 432
                cortisol and, 336          nomenclature of, 220     Carpal bones, 449         CD21 protein, 110
                nystatin, 199              thyroid, 343             Carpal tunnel syndrome, 459  viral receptor, 166
               Cannibalism, 178          Cardiac arrest               lunate dislocation, 449  CD25 protein
               “Cannonball” metastases, 642  antacid adverse effects, 399  nerve injury, 447    cell surface protein, 110
               Capecitabine                hypermagnesemia, 591       rheumatoid arthritis, 466  regulatory T cells and, 102
                5-F-dUMP, 36             Cardiac cycle, 287         Carteolol, 552            CD28 protein, 110
               “Cape-like” sensory loss, 492  Cardiac depression, 318  Cartilage              CD34 protein, 110
               Capillary fluid exchange, 297  Cardiac function curves, 286  collagen in, 50     leukocyte extravasation and, 215
               Capitate bone, 449        Cardiac glycosides           fluoroquinolone damage to, 250  CD40 protein, 110
               Capitation, 271             mechanism and clinical use, 321  Cartilage damage, 204  CDKN2A gene, 224
               Caplan syndrome, 466, 677   sodium-potassium pump    Carvedilol, 245, 323      CEA tumor marker, 388
               Capsules (bacterial), 124        inhibition, 49      Casal necklace, 67        Cefaclor, 189
               Captain’s wheel           Cardiac looping, 280       Caseating granulomas      Cefazolin
                Paracoccidioidomycosis, 151  Cardiac output           in tuberculosis, 140      mechanism and use, 189
               Captopril, 610              exercise and, 670        Case-control studies, 256   prophylaxis, 198
               Caput medusae, 365          in pregnancy, 633        Caseous necrosis, 209     Cefepime
               Carbachol, 240, 552         variables in, 284        Caspases, 208               mechanism and use, 189
               Carbamazepine               V/Q mismatch and, 669    Caspofungin                 Pseudomonas aeruginosa, 143
                agranulocytosis, 250     Cardiac output equations, 285  echinocandins, 200    Cefotaxime, 189
                aplastic anemia, 250     Cardiac pressures (normal), 297  Casts in urine, 594  Cefotetan
                cytochrome P-450 and, 252  Cardiac tamponade, 310   Catabolism of amino acids, 82  mechanism and use, 189
                epilepsy, 544              aortic dissection and, 303  Catalase, 210          Cefoxitin
                SIADH and, 249             jugular venous pulse in, 287  Catalase-positive organisms, 128  mechanism and use, 189
               Carbamoyl phosphate, 82     MI, 305, 307             Cataplexy, 568            Cefpodoxime
               Carbamoyl phosphate synthetase, 73  shock, 310       Cataracts, 535              mechanism and use, 189
               Carbapenems               Cardiac therapy, 317         corticosteroid toxicity, 120  Ceftaroline
                mechanism and use, 190   Cardiac tumors, 316          diabetes mellitus and, 346  mechanism and use, 189
                Pseudomonas aeruginosa, 143  Cardinal veins, 281      galactosemia, 80          MRSA, 198







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