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776                       INDEX                                                                                                                                                                             INDEX




               IgD antibodies, 105         fungal infections, 186     pituitary, 339          Inguinal hernia, 370
               IgE antibodies, 105         Listeria monocytogenes, 139  regions susceptible to, 210  Inguinal ligament, 368, 369
                ataxia-telangiectasia, 117  Pneumocystis jirovecii, 154  types of, 210        Inguinal triangle, 370
                eczema, 477              Immunodeficiency syndromes  IFN-β (Interferon-β)     Inhalational injury, 676
                hyper-IgM syndrome, 117    flow cytometry diagnosis, 54  clinical uses, 121   Inhaled anesthetics, 550
                mast cells and, 408        infections in, 118         natural killer cells, 101  Inheritance modes, 59
                type I hypersensitivity, 112  syndromes, 116–117    Infections                Inhibin
               IgG antibodies, 105       Immunoglobulin A vasculitis, 315  ESR in, 214          Sertoli cell secretion of, 628
                ataxia-telangiectasia, 117  Immunoglobulins           in immunodeficiency, 118  Inhibitors of complement activation,
                complement activation and, 106  adaptive immunity and, 99  Inferior colliculi, 504   106
                hepatitis A (HAV), 174     breast milk and, 636     Inferior gluteal nerve, 453  Inhibitory pathway, 500
                multiple sclerosis, 523    isotypes of, 105         Inferior mesenteric artery, 363, 364  Injury (unintentional), 272
                as passive immunity, 110   for Kawasaki disease, 314  horseshoe kidney, 579   Innate immune system
                type II hypersensitivity reaction,   Immunohistochemical stains, 227  Inferior oblique muscle, 540  in acute inflammation, 214
                     480                 Immunology, 96–122         Inferior rectal artery, 366  Innate immunity, 99
                type III hypersensitivity reactions,   cellular components, 98  Inferior rectal vein, 365  Inositol trisphosphate (IP ), 337
                                                                                                               3
                     113                   immune responses, 104–117  Inferior rectus muscle, 540  Inotropes, 310
               IgM antibodies, 105         immunosuppressants, 120–122  Inferior sagittal sinus, 503  Inotropy, 286
                in biliary cirrhosis, 395  lymphoid structures, 96–98  Inferior vena cava, 360  INR (international normalized ratio),
                complement activation and, 106  pathogen recognition in, 99  diaphragm, 663          426
                hepatitis A (HAV), 174   Immunomodulator signaling    gonadal drainage and, 624  Insomnia
                hyper-IgM syndrome, 117         pathways, 337       Infertility                 barbiturates for, 546
                overproduction, 431      Immunophenotype assessment, 54  clomiphene, 656        nonbenzodiazepine hypnotics, 546
                in sclerosing cholangitis, 395  Immunosuppressants    cystic fibrosis, 60       ramelteon for, 547
                splenic dysfunction, 98    for aplastic anemia, 421   ectopic pregnancy, 641    stimulants causing, 570
               Ileum, 362                  targets, 121               Kallmann syndrome, 639    suvorexant, 547
                basal electric rhythm, 362  transplant rejection, 120  Kartagener syndrome, 49  Inspiratory capacity (IC), 664
               Ileus, 386                Immunosuppression            leuprolide for, 656     Inspiratory reserve volume (IRV), 664
                bacterial peritonitis (spontaneous),   vitamin A deficiency, 66  mumps, 170   Insulin, 334
                     390                   vitamin C deficiency, 69   salpingitis, 185          anabolic effects of, 334
                gallstone, 396           Immunotherapy, 121           septate uterus, 623       diabetic ketoacidosis, 347
               Iliacus, 452              Impaired colleague, 269      varicoceles, 651          fructose bisphosphatase-2 and, 76
               Iliohypogastric nerve, 452  Imperforate hymen, 644   IFN-γ (Interferon-γ), 108, 116  GIP effect on, 371
               Iliotibial band syndrome, 461  Impetigo, 136, 475      clinical uses, 121        glucagon and, 333
               Illness anxiety disorder, 566  crusts with, 479      Infiltrative cardiomyopathy, 308  glycogen regulation, 73, 85
               Iloperidone, 573          Imprinting disorders, 58   Inflammasome, 214            hypokalemia from, 590
               Imatinib, 433, 443        Inactivated (killed) vaccine, 111  Inflammation        potassium shifts wit, 590
               IMG registration timeframe, 6  Incidence vs prevalence, 259  acute, 214          in pregnancy, 334
               Imipenem                    in medical error corrections, 259  in atherosclerosis, 302  production of, 329
                seizures with, 251       Inclusions                   cardinal signs, 213       secretion of, 334
               Imipramine, 575             Cowdry A, 166              chronic, 216              somatostatin and, 371
               Immature ego defenses, 555  mulberry-like (morulae), 150  ESR in, 214            somatostatinomas and, 351
               Immature teratoma, 647      Negri bodies, 171          Extrinsic (death receptor) pathway,   Insulin deficiency, 590
               Immune checkpoint interactions,    “owl eye,” 165          208                   diabetes mellitus diagnosis, 346
                     222                   reticulate bodies, 148     IL-1 in, 108            Insulin-like growth factor 1 (IGF-1)
               Immune complex, 113       Incomplete penetrance, 56    Intrinsic (mitochondrial) pathway,   acromegaly, 339
               Immune evasion            Incontinence (fecal/urinary), 453  208                 signaling pathways for, 337
                in cancer, 221           Incus, 533, 620              wound healing, 216      Insulinoma, 351
               Immune responses          Incus (ossicles)           Inflammatory bowel disease (IBD),   insulin and C-peptide in, 334
                acute-phase reactants, 102  pharyngeal arch derivative, 620  382                MEN 1 syndrome, 351
                antibody structure and function,   India ink stain, 125  azathioprine for, 440  pancreatic cell tumor, 351
                     104–117             Indicator media, 126         colorectal cancer and, 388  Insulin preparations, 352
                antigen type and memory, 105  Indinavir               erythema nodosum, 482   Insulin resistance, 633
                Bordetella pertussis, 143  HIV therapy, 203           infliximab/adalimumab for, 487  acanthosis nigricans and, 482
                cell surface proteins, 110  Indirect bilirubin, 375   methotrexate for, 440     acromegaly, 339
                complement, 106          Indirect cholinomimetic agonists, 240  sclerosing cholangitis and, 395  cortisol, 336
                cytokines, 108           Indirect Coombs test         spondyloarthritis, 469    DM type 2, 347
                hypersensitivity types, 114–115  unbound antibody detection, 112  therapeutic antibodies, 122  GH, 329
                immunoglobulin, 105      Indirect inguinal hernia, 370  Inflammatory breast disease, 649, 650  non-alcoholic fatty liver disease,
                passive vs active, 110   Indirect sympathomimetics, 242  Inflammatory demyelinating   391
                respiratory burst, 109   Indirect (unconjugated)          polyradiculopathy, 524  polycystic ovarian syndrome, 645
                Salmonella/Shigella spp, 144    hyperbilirubinemia, 393  Infliximab, 122, 487  Insurance
                transfusion reactions, 114  Indomethacin, 486         for Crohn disease, 382    disregarding in treatment, 269
               Immune system organs        for diabetes insipidus, 338  for ulcerative colitis, 382  Medicare/Medicaid as, 272
                cellular components, 99  IFN-α (Interferon-α)       Influenza, 169              types of plans, 271
                lymph nodes, 96            clinical uses, 121         orthomyxovirus, 167     Integrase inhibitors, 203
                thymus, 98                 myopathy, 250              pneumonia, 683          Integrins
               Immunocompromised patients  natural killer cells, 101  treatment/prevention, 201  epithelial cells, 474
                acyclovir/famciclovir/valacyclovir,   Infant development, 635  Informed consent, 265  viral receptor, 166
                     201                 Infarction                 Infraspinatus muscle      Intellectual disability, 557
                Candida albicans in, 153   blood-brain barrier effects, 496  Erb palsy, 448     autism and, 557
                common organisms affecting, 179  of bone, 463         rotator cuff, 446         cri-du-chat syndrome, 64
                Cryptococcus neoformans, 153  Infarcts              Infundibulopelvic ligament, 625  Down syndrome, 63
                Cryptosporidium, 155       atherosclerosis, 302     Ingested seafood toxins, 247  Lesch-Nyhan syndrome, 37
                esophagitis in, 377        calcification in, 211    Inguinal canal, 369         Patau syndrome, 63








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