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784                       INDEX                                                                                                                                                                             INDEX




               Necrosis (continued)        jaundice in, 393         Neuroblastomas, 350         IL-8 and, 108
                hernias and, 370           kernicterus, 194, 204      incidence and mortality, 222  innate immunity, 99
                jaw, 486                   Listeria monocytogenes in, 139  oncogenes and, 224   left shift, 424
                mesenteric ischemia, 386   low birth weight, 635      paraneoplastic syndromes with, 228  in leukocyte adhesion deficiency,
                nonalcoholic fatty liver disease,    meningitis in, 182  Neurocutaneous disorders, 525  117
                     391                   necrotizing enterocolitis and, 386  Neurodegenerative disorders,   LTB4, 485
                saponification, 209        obesity risk factors, 636      520–522               megaloblastic anemia, 420
                scaphoid avascular, 449    pneumonia in, 149          drug therapy for, 549     in MI, 305
                transplant reaction, 119   primitive reflexes in, 510  Neuroectoderm, 490       necrosis and, 209
                warfarin, 436              sickle cell anemia in, 422  derivatives of, 612      nonmegaloblastic anemia, 420
               Necrotizing enterocolitis, 386  Streptococcus agalactiae in, 137  pituitary gland, 327  pseudo-Pelger-Huet anomaly, 432
               Necrotizing fasciitis, 479  TORCH manifestations in, 182  Neuroendocrine tumors, 350  stimulation of, 44
                Streptococcus pyogenes (Group A   Neoplasia         Neurofibromatosis, 535      wound healing, 216
                     strep), 136           pathology of, 219–226, 518  chromosome association, 64  Nevi, 220
               Necrotizing glomerulonephritis, 315  Neoplastic progression, 219  inheritance, 60  Nevirapine
               Negative predictive value (NPV), 257  Neoplastic transformation, 216  tumor suppressor genes and, 224  cytochrome P-450 and, 252
               Negative punishment, 554    adenomatous polyps, 387    typesI and II, 525        HIV therapy, 203
               Negative reinforcement, 554  Neostigmine, 240          variable expressivity, 56  NF1/NF2 genes, 224
               Negative skew distribution, 262  Nephritic-nephrotic syndrome  Neurofilaments  N-formylmethionine (fMet), 44
               Negative-stranded viruses, 168  etiology and presentation, 595  cytoskeletal element, 48  NF-κB, 120
               Neglect (child), 556      Nephritic syndrome, 596–597  immunohistochemical stain for,   Niacin
               Negri bodies, 171           etiology and presentation, 595  227                  cutaneous flushing, 248
               Neisseria gonorrhoeae     Nephritis, 608             Neurogenic ileus, 240       gout, 250
                culture requirements, 126  Nephroblastoma, 606      Neurohypophysis, 327        hyperglycemia, 249
                epididymitis and orchitis, 654  Nephrocalcinosis, 211  hypothalamus and, 498    myopathy caused by, 250
                osteomyelitis, 180       Nephrogenic diabetes insipidus, 211,   Neuroleptic malignant syndrome   Nicardipine, 318
                septic arthritis, 468           338                       (NMS), 551, 569     Nicotinamides, 75
                STI, 184                   lithium toxicity, 569    Neurological signs        Nicotine
                UTIs with, 600             treatment, 609             proximal upper and lower   intoxication and withdrawal, 571
               Neisseria meningitidis    Nephrolithiasis, 606             extremity, 502        teratogenicity, 614
                chloramphenicol, 192       calcium oxalate, 69      Neurologic drug reactions, 251  Nicotinic acetylcholine receptors,
                culture requirements, 126  Nephron physiology, 585  Neurology and special senses,    166, 236
                encapsulation, 127       Nephropathy                      490–544             Niemann-Pick disease, 88
                meningitis, 180            diabetes mellitus, 346     anatomy/physiology, 493–515  Nifedipine, 316, 318, 643
                penicillin G/V for, 187    hypertension and, 300      embryology, 490–492     Nifurtimox, 158, 200
                Waterhouse-Friderichsen    protease inhibitors, 203   ophthalmology, 534–541  Night terrors
                     syndrome, 349         transplant rejection, 119  otology, 533–534          benzodiazepines for, 497
               Neisseria spp             Nephrotic syndrome, 597      pathology, 511–518      Nigrostriatal pathway, 499
                C5-C9 deficiencies, 107    early-onset, 606           pharmacology, 544–551   Nikolsky sign
                cephalosporins, 189        ESR in, 214              Neuromuscular blocking drugs, 551  blistering skin disorders, 480
                fluoroquinolones, 195      etiology and presentation, 595  Neuromuscular disorders  scalded skin syndrome, 479
                gram-negative algorithm, 142  fatty casts in, 594     paraneoplastic syndromes, 228  Nilotinib, 443
                IgA protease, 129          TBG and, 331             Neuromuscular junction    Nimodipine, 318, 513
                intracellular organism, 127  Nephrotoxicity           skeletal muscle, 236    Nipple
                transformation in, 130     aminoglycosides, 191       diseases of, 472          intraductal papilloma, 649
               Nelson syndrome, 348        amphotericin B, 199      Neurons, 493                lactational mastitis, 649
               Nematodes, 159              cidofovir, 202             in ascending spinal tracts, 509  Nissl bodies, 46
                infection routes, 158      cisplatin/carboplatin, 442  local anesthetics, 550  Nissl substance
               Neomycin                    cladribine, 440            origins of, 490           chromatolysis, 495
                aminoglycosides, 191       drug reaction and, 251     Parkinson disease, 548    neurons, 493
               Neonatal abstinence syndrome, 615  drugs causing, 444  primary motor cortex, 509  Nitazoxanide, 155
               Neonatal conjunctivitis     immunosuppressants, 120  Neuron-specific enolase, 226, 350  Nitrates, 319
                Chlamydia trachomatis, 149  inhaled anesthetics, 550  Neuropathic pain, 515     mechanism and clinical use, 318
               Neonatal pneumonia          streptomycin, 197        Neuropathy                Nitric oxide, 371
                Group B streptococci, 179  sulfonamides, 194          diabetes mellitus, 346    free radical injury and, 210
               Neonatal respiratory distress   Nerve blockade (local anesthetics),   Neurosyphilis, 147  Nitrites
                     syndrome (NRDS), 661       550                 Neurotoxicity               urinary tract infections, 181
               Neonates                  Nerve fibers, 495            cladribine, 440         Nitroblue tetrazolium dye reduction
                abstinence syndrome, 615  Nerves                      immunosuppressants, 120        test, 117
                Apgar score, 634           lower extremity, 452, 453  methylmercury exposure, 614  Nitrofurantoin
                Candida albicans in, 153   upper extremity, 446, 447  methylxanthines, 687      hemolysis in G6PD deficiency, 250
                coagulation cascade in, 413  Nerve trunk, 495         vincristine, 441          pulmonary fibrosis, 251
                conjunctivitis, 142, 149  Nesiritide, 296           Neurotransmitters         Nitroglycerin, 318
                deprivation effects, 556  Neural crest                bacterial toxin effects, 132  acute coronary syndromes, 307
                esophageal atresia in, 359  derivatives of, 613       changes with disease, 495  angina, 304
                flora with C-section, 178  Neural crest cells, 490, 494  vomiting center receptors, 496  Nitroprusside, 318
                galactosemia in, 80      Neural development, 490    Neurovascular pairing, 455  Nitrosamines
                gastroenteritis, 168     Neural plate, 490          Neutralization (antibody), 104  as carcinogens, 225
                gray baby syndrome in, 192  Neural tube, 490        Neutropenia, 424            stomach cancer and, 379
                hemolytic anemia in, 422   derivatives, 613           ganciclovir, 202        Nitrosoureas, 441
                herpes in, 164             formation, 612             rheumatoid arthritis, 466  Nitrous oxide, 550
                hyperthermia in, 241     Neural tube defects, 491     ticlopidine, 437        Nizatidine, 399
                hypertrophic pyloric stenosis in,   maternal diabetes, 614  Neutrophils, 406  NMDA receptor antagonist
                     359                   prevention, 68             chemotaxis, 44, 106, 133, 406, 485,   ketamine as, 550
                indirect inguinal hernia in, 370  valproic acid, 544      487, 691              memantine as, 549
                intraventricular hemorrhage, 512  Neuraminidase, 169–170  corticosteroid effect on, 424  N-myc oncogene, 350







          FAS1_2019_21_Index_749-806.indd   784                                                                        11/21/19   12:27 PM
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