Page 158 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

B. Respiratory acidosis
Bicarbonate buffer Non-bicarbonate buffer (NBB)
– NBB – NBB-H
HCO 3
CO 2
8.0 8.0
7.5 7.5
7.0 7.0
normal: pH 7.4
Acidosis and Alkalosis II
Decreased pulmonary
CO 2
elimination of CO 2

–
HCO 3 + H + CO 2 +H 2 O 1
H +
Buffering
–
NBB + H + NBB-H
Plate 6.4

–
Respiratory acidosis: pH Buffering by NBB only

– +
2HCO 3 +2NH 4 Urea
Kidney
2
Liver H 2 O + CO 2 Renal compensation

+ –
H +HCO 3 CO 2
Increased
excretion Increased pulmonary elimination of CO 2
H +
+
NH 4 Increased
production (kidney)
– and sparing (liver)
HCO 3
–
HCO 3
–
+
HCO 3 + H → CO 2 +H 2 O

Renal compensation of acidosis NBB is regenerated
is achieved: pH
145
–
But: [HCO 3 ]act and P CO 2 are increased
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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