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                                                                                   C HAPTER 2 5 / Cardiac Surgery  605
                   Pulmonary                                           antibiotics and digoxin, must be adjusted for decreased renal
                   Routinely, patients are intubated and ventilated for 2 to 4 hours  clearance.  When renal failure after cardiac surgery is severe
                   after cardiac surgery. Pulmonary function is monitored with con-  enough to require renal replacement therapy, the mortality rate is
                   tinuous pulse oximetry as well as intermittent arterial blood gases  close to 60%. 46
                   and chest radiographs. Mild pulmonary dysfunction is common
                   after cardiac surgery. Pathophysiologic changes that occur after  Gastrointestinal
                   CPB include increased capillary  permeability, increased  pul-  Serious gastrointestinal complications can occur after cardiac
                   monary vascular resistance, and intrapulmonary aggregation of  surgery. Abdominal distention can occur during the first days af-
                   leukocytes and platelets. A noncardiac pulmonary edema may oc-  ter surgery secondary to decreased motility related to anesthesia,
                   cur immediately after CPB or during the first several days after  narcotics, and diabetic gastroparesis. If ileus and abdominal dis-
                   surgery. Comparative studies between OPCAB and CABG with  tention do not resolve with fasting and suppository or enema
                   CPB suggest that CPB alone may not be the major cause of the  treatments, the etiology of the distention should be explored
                                                              9
                   development of postoperative pulmonary dysfunction. In a  further. Gastroduodenal bleeding can result from erosive gastri-
                                                    43
                   prospective, controlled trial by Roosens et al., both patients with  tis or esophagitis, or frank ulceration, especially in patients with
                   and without CPB had dramatic impairment of respiratory system  a previous history of peptic ulcer disease. Patients after cardiac
                   mechanic postoperatively. Severe pulmonary dysfunction is un-  surgery usually are placed on prophylactic gastrointestinal agents
                   common and may be related to preexisting lung disease. Although  such as antacids, sucralfate, histamine blockers such as famoti-
                   severe lung injury after cardiac surgery is rare, it continues to be a  dine or ranitidine, or proton-pump inhibitors such as pantopra-
                   major impact on morbidity and mortality as well as related cost of  zole. Cholecystitis presents with right upper quadrant pain and
                               9
                   hospitalization. In a case controlled study by Milot et al. 44  in  can be evaluated with abdominal  ultrasound. After cardiac
                   3,278 patients, adult respiratory distress syndrome after cardiac  surgery or critical illness, cholecystitis commonly occurs in its
                   surgery was rare (0.4%) but carried a 15% mortality rate. Inde-  acalculous (no stones) form. Mild elevations of hepatic transam-
                   pendent predicators of adult respiratory distress syndrome in car-  inases also occur commonly after CPB. Severe hepatic dysfunc-
                   diac surgery patients include number of blood products trans-  tion or “shock liver syndrome” with massive increases in liver en-
                   fused, shock, and previous cardiac surgery. 44  Chest radiographs  zymes most often occurs as a result of global hypoperfusion and
                   should be performed as part of the fever work-up to rule out at-  end-organ damage. Acute hemorrhagic pancreatitis is uncom-
                   electasis and pneumonia. Atelectasis may occur secondary to hy-  mon after CABG surgery, but it has high rates of mortality and
                   poventilation related to sternal incision discomfort. Pain from  morbidity. If the patient continues to remain acidotic and the
                   chest tubes and sternotomy incision interferes with normal respi-  diagnostic work-up fails to identify another cause, abdominal
                   ration and pulmonary toilet, making adequate pain control a high  exploration is done in the hope of finding a correctable source
                   priority. Diminished breath sounds and lung fields at the bases  such as necrotic bowel. Diarrhea may occur with enteral feed-
                   that are dull to percussion indicate significant pleural effusions.  ings and medications such as quinidine or procainamide, or may
                   Pneumothorax may occur any time during the postoperative pe-  be the result of Clostridium difficile infection. Patients with diar-
                   riod or at the time of pleural chest tube removal. Phrenic nerve  rhea should have stool samples sent to test for C. difficile toxin
                   damage may result in diaphragmatic paralysis or dysfunction but  and are treated with oral administration of metronidazole or
                   is uncommon with today’s surgical techniques.       vancomycin.
                     Pulmonary embolism is uncommon after cardiac surgery. Fac-
                   tors associated with a higher incidence of pulmonary emboli in-  Neuropsychological
                   clude AF, heart failure, obesity, hypercoagulable states, and im-  Neuropsychological dysfunction after cardiac surgery can be ei-
                   mobilization. Diagnostic work-up for pulmonary emboli includes  ther central or peripheral. Cognitive decline after CPB has been
                   arterial blood gas, ventilation perfusion scan, CT scan, or pul-  estimated from 3% to 50%, depending on definitions and time of
                   monary angiogram. Treatment with continuous intravenous he-  assessment and stroke in approximately 3% of patients undergo-
                   parin is begun once the diagnosis of pulmonary emboli is estab-  ing CABG surgery. 18  Embolization is the most common etiology
                   lished, and warfarin is started for long-term anticoagulation. In  of stroke during cardiac surgery but hypoperfusion may also play
                   patients in whom anticoagulation is contraindicated, an inferior  a role. 47
                   vena caval filter may be placed. Surgical pulmonary embolectomy  Two types of peripheral neurologic deficits, brachial plexus in-
                   may be used in patients with large pulmonary emboli and associ-  jury and ulnar nerve injury, are described after cardiac surgery.
                   ated clinical presentation of right-side heart failure.  The brachial plexus is susceptible to stretch injury and can occur
                                                                                                                   48
                                                                       with sternal retraction is a key factor responsible for injury. In
                   Renal                                               addition to a history of upper extremity pain and paresthesia, ex-
                   While the pathogenesis of renal failure after cardiac surgery is  amination for brachial plexus injury includes evaluation of motor
                   multifactorial, CPB represents a specific risk.  45  Radiocontrast  function of muscle groups innervated by the brachial plexus and
                                                                                       48
                   used during coronary angiography before cardiac surgery can fur-  sensation to pin prick. Ulnar nerve injury, a result of nerve com-
                   ther reduce renal function. Nonoliguric renal failure after cardiac  pression, is frequently described by patients after cardiac surgery
                   surgery occurs most commonly after cardiac surgery. If renal dys-  as paresthesias in the affected arm below the elbow in the ulnar
                   function progresses to oliguric renal failure, serum potassium lev-  distribution involving the third, fourth, and fifth digits.
                   els may increase rapidly and maintenance of normovolemia may  Postcardiotomy delirium occurs 2 to 5 days after cardiac sur-
                   be difficult without hemofiltration or dialysis. Nephrotoxic med-  gery and is manifested as mild confusion, somnolence, agitation,
                   ications such as aminoglycoside antibiotics, radiographic contrast,  or hallucinations. Memory and alertness are frequently preserved
                   and nonsteroidal anti-inflammatory drugs must be avoided in  but psychosis may occur. 47  While postcardiotomy delirium is
                   postoperative renal failure, and many other medications, such as  usually self-limiting, it may put the patient at increased risk for
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