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Cardiovascular Alterations


                                                          and Management                                  10





                                                                                Robyn Gallagher
                                                                                 Andrea Driscoll



               Learning objectives                                  Key words


               After reading this chapter, you should be able to:   arrhythmia
               ●   explain the pathophysiology of coronary artery disease,   acute coronary syndrome
                   clinical manifestations of acute coronary syndromes and   myocardial infarction
                   management of events                             percutaneous coronary intervention
               ●   discuss the collaborative care for a patient with chest pain  acute heart failure
               ●   list the diagnostic tests used to assess myocardial ischaemia  left ventricular failure
               ●   outline the actions and contraindications of thrombolytic   right ventricular failure
                   drugs                                            aortic aneurysm
               ●   outline the clinical manifestations of right and left   endocarditis
                   ventricular failure                              cardiomyopathy
               ●   discuss the goals of heart failure treatment     hypertensive emergencies
               ●   discuss the pathophysiology of the four different types of   ventricular aneurysm
                   cardiomyopathy and how it affects cardiac function
               ●   outline the actions of angiotensin converting enzyme
                   inhibitors, beta-blockers, loop diuretics and spironolactone
                   and how they relate to the pathophysiology of heart failure  CORONARY HEART DISEASE

                                                                  Coronary heart disease (CHD) is the term used to describe
                                                                  the  effects  of  a  reduction  or  complete  obstruction  of
                                                                  blood flow through the coronary arteries due to narrow-
             INTRODUCTION                                         ing  from  atherosclerosis  and/or  thrombus.  Although
                                                                  some  patients  may  be  asymptomatic,  the  commonest
             This chapter reviews the support of cardiovascular func-  manifestations  of  CHD  are  chest  pain  due  to  angina,
             tion in the face of many compromises to the system. It   acute  coronary  syndrome  (ACS,  a  term  used  to  collec-
             focuses on two of the most prevalent and fatal diseases   tively  describe  acute  myocardial  infarction  [AMI]  and
             affecting  the  heart:  coronary  heart  disease  and  heart   unstable angina) and sudden death. CHD may also cause
             failure. These diseases are also a common co-morbidity   arrhythmias and heart failure. 1
             in elderly patients admitted to critical care units. The first
             section on coronary heart disease reviews the pathophysio-  CHD is the leading cause of death, premature death and
                                                                                                     2,3
             logical concepts of myocardial ischaemia and associated   disability in Australia and New Zealand.  In 2007, more
             complications, with detailed consideration of the clinical   than 22,000 people died of CHD in Australia, more than
                                                                                                                 2-4
             implications,  assessment  and  associated  management.   5000 in New Zealand in 2004 and 7.2 million worldwide.
             Heart failure is discussed in terms of the body’s compen-  Death rates have fallen by about 76% since the 1960s,
             satory mechanisms and the clinical sequelae and associ-  primarily due to improvements in risk factors and health
             ated clinical features of heart failure. Nursing and medical   care  for  those  at  risk.  However,  the  burden  of  CHD
             management  is  outlined  including  the  management  of   remains high, with 1.5% of Australians reporting CHD
                                                                           2
             acute exacerbations of heart failure. Finally, other cardio-  symptoms.   Furthermore,  CHD  is  the  single  leading
             vascular  disorders  commonly  managed  in  critical  care   health problem worldwide because of a rising incidence
                                                                                       4
             units  are  reviewed  ranging  from  other  forms  of  heart   in developing countries.
             failure to hypertensive emergencies and aortic aneurysms.
             The case study presented at the end of the chapter high-  MYOCARDIAL ISCHAEMIA
             lights  the  key  aspects  of  the  management  of  coronary   When coronary blood flow is insufficient to meet myo-
             heart  disease  and  heart  failure  in  patients  admitted  to   cardial tissue demand for oxygen, myocardial ischaemia
             critical care units.                                 occurs. Critical restriction to blood flow occurs when the   215
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