Page 142 - Hematology_ Basic Principles and Practice ( PDFDrive )

Chapter 9 Hematopoietic Stem Cell Biology 110.e3

that includes giving rise to CD34+ cells. Exp Hematol 26:353–360, 117. Purton LE, et al: RARgamma is critical for maintaining a balance
1998. between hematopoietic stem cell self-renewal and differentiation. J Exp
95. Gao Z, et al: Human CD34+ cell preparations contain over 100-fold Med 203:1283–1293, 2006. doi: 10.1084/jem.20052105.
greater NOD/SCID mouse engrafting capacity than do CD34- cell 118. Rosendaal M, Hodgson GS, Bradley TR: Organization of haemopoietic
preparations. Exp Hematol 29:910–921, 2001. stem cells: the generation-age hypothesis. Cell Tissue Kinet 12:17–29,
96. Baum CM, Weissman IL, Tsukamoto AS, et al: Isolation of a candidate 1979.
human hematopoietic stem-cell population. Proc Natl Acad Sci USA 119. Adams GB, et al: Stem cell engraftment at the endosteal niche is speci-
89:2804–2808, 1992. fied by the calcium-sensing receptor. Nature 439:599–603, 2006. doi:
97. Petzer AL, Zandstra PW, Piret JM, et al: Differential cytokine effects on 10.1038/nature04247.
primitive (CD34+CD38-) human hematopoietic cells: novel responses 120. Cancelas JA, et al: Rac GTPases differentially integrate signals regulat-
to Flt3-ligand and thrombopoietin. J Exp Med 183:2551–2558, 1996. ing hematopoietic stem cell localization. Nat Med 11:886–891, 2005.
98. Majeti R, Park CY, Weissman IL: Identification of a hierarchy of doi: 10.1038/nm1274.
multipotent hematopoietic progenitors in human cord blood. Cell Stem 121. Ema H, et al: Adult mouse hematopoietic stem cells: purification
Cell 1:635–645, 2007. doi: 10.1016/j.stem.2007.10.001. and single-cell assays. Nat Protoc 1:2979–2987, 2006. doi: 10.1038/
99. McKenzie JL, Takenaka K, Gan OI, et al: Low rhodamine 123 nprot.2006.447.
retention identifies long-term human hematopoietic stem cells within 122. Ema H, et al: Quantification of self-renewal capacity in single hema-
the Lin-CD34+CD38- population. Blood 109:543–545, 2007. doi: topoietic stem cells from normal and Lnk-deficient mice. Dev Cell
10.1182/blood-2006-06-030270. 8:907–914, 2005. doi: 10.1016/j.devcel.2005.03.019.
100. Notta F, et al: Isolation of single human hematopoietic stem cells 123. Janzen V, et al: Stem-cell ageing modified by the cyclin-dependent
capable of long-term multilineage engraftment. Science 333:218–221, kinase inhibitor p16INK4a. Nature 443:421–426, 2006. doi: 10.1038/
2011. doi: 10.1126/science.1201219. nature05159.
101. Chitteti BR, et al: CD166 regulates human and murine hematopoietic 124. Walkley CR, Fero ML, Chien WM, et al: Negative cell-cycle regula-
stem cells and the hematopoietic niche. Blood 124:519–529, 2014. doi: tors cooperatively control self-renewal and differentiation of haema-
10.1182/blood-2014-03-565721. topoietic stem cells. Nat Cell Biol 7:172–178, 2005. doi: 10.1038/
102. Quarmyne M, et al: Protein tyrosine phosphatase-sigma regulates hema- ncb1214.
topoietic stem cell-repopulating capacity. J Clin Invest 125:177–182, 125. Muramoto GG, et al: Inhibition of aldehyde dehydrogenase expands
2015. doi: 10.1172/JCI77866. hematopoietic stem cells with radioprotective capacity. Stem Cells
103. Schmitt TM, Zuniga-Pflucker JC: Induction of T cell development 28:523–534, 2010. doi: 10.1002/stem.299.
from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 126. Yang L, et al: Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-
17:749–756, 2002. term hematopoietic stem cells capable of rapidly reconstituting and
104. Whitlock CA, Witte ON: Long-term culture of B lymphocytes and rescuing myeloablated transplant recipients. Blood 105:2717–2723,
their precursors from murine bone marrow. Proc Natl Acad Sci USA 2005. doi: 10.1182/blood-2004-06-2159.
79:3608–3612, 1982. 127. Sieburg HB, et al: The hematopoietic stem compartment consists of
105. van Os R, Kamminga LM, de Haan G: Stem cell assays: something old, a limited number of discrete stem cell subsets. Blood 107:2311–2316,
something new, something borrowed. Stem Cells 22:1181–1190, 2004. 2006. doi: 10.1182/blood-2005-07-2970.
doi: 10.1634/stemcells.2004-0095. 128. Bryder D, Rossi DJ, Weissman IL: Hematopoietic stem cells: the
106. Brandt JE, et al: Ex vivo expansion of autologous bone marrow paradigmatic tissue-specific stem cell. Am J Pathol 169:338–346, 2006.
CD34(+) cells with porcine microvascular endothelial cells results in a doi: 10.2353/ajpath.2006.060312.
graft capable of rescuing lethally irradiated baboons. Blood 94:106–113, 129. Dick JE, Magli MC, Huszar D, et al: Introduction of a selectable gene
1999. into primitive stem cells capable of long-term reconstitution of the
107. Himburg HA, et al: Pleiotrophin regulates the expansion and regen- hemopoietic system of W/Wv mice. Cell 42:71–79, 1985.
eration of hematopoietic stem cells. Nat Med 16:475–482, 2010. doi: 130. Keller G, Snodgrass R: Life span of multipotential hematopoietic stem
10.1038/nm.2119. cells in vivo. J Exp Med 171:1407–1418, 1990.
108. Harrison DE: Competitive repopulation: a new assay for long-term 131. Spangrude GJ, Brooks DM, Tumas DB: Long-term repopulation of
stem cell functional capacity. Blood 55:77–81, 1980. irradiated mice with limiting numbers of purified hematopoietic stem
109. Harrison DE, Jordan CT, Zhong RK, et al: Primitive hemopoietic cells: in vivo expansion of stem cell phenotype but not function. Blood
stem cells: direct assay of most productive populations by competitive 85:1006–1016, 1995.
repopulation with simple binomial, correlation and covariance calcula- 132. Zhong RK, Astle CM, Harrison DE: Distinct developmental patterns
tions. Exp Hematol 21:206–219, 1993. of short-term and long-term functioning lymphoid and myeloid precur-
110. Yuan R, Astle CM, Chen J, et al: Genetic regulation of hematopoietic sors defined by competitive limiting dilution analysis in vivo. J Immunol
stem cell exhaustion during development and growth. Exp Hematol 157:138–145, 1996.
33:243–250, 2005. doi: 10.1016/j.exphem.2004.10.014. 133. Randall TD, Weissman IL: Phenotypic and functional changes induced
111. Szilvassy SJ, Humphries RK, Lansdorp PM, et al: Quantitative at the clonal level in hematopoietic stem cells after 5-fluorouracil treat-
assay for totipotent reconstituting hematopoietic stem cells by a com- ment. Blood 89:3596–3606, 1997.
petitive repopulation strategy. Proc Natl Acad Sci USA 87:8736–8740, 134. Szilvassy SJ, Ragland PL, Miller CL, et al: The marrow homing
1990. efficiency of murine hematopoietic stem cells remains constant during
112. Szilvassy SJ, Lansdorp PM, Humphries RK, et al: Isolation in a single ontogeny. Exp Hematol 31:331–338, 2003.
step of a highly enriched murine hematopoietic stem cell population 135. Muller-Sieburg CE, Sieburg HB: Clonal diversity of the stem cell com-
with competitive long-term repopulating ability. Blood 74:930–939, partment. Curr Opin Hematol 13:243–248, 2006. doi: 10.1097/01.
1989. moh.0000231421.00407.65.
113. Taswell C: Limiting dilution assays for the determination of immuno- 136. Trentin JJ: Determination of bone marrow stem cell differentiation by
competent cell frequencies. I. Data analysis. J Immunol 126:1614–1619, stromal hemopoietic inductive microenvironments (HIM). Am J Pathol
1981. 65:621–628, 1971.
114. Jordan CT, Lemischka IR: Clonal and systemic analysis of long-term 137. Metcalf D: Lineage commitment and maturation in hematopoietic
hematopoiesis in the mouse. Genes Dev 4:220–232, 1990. cells: the case for extrinsic regulation. Blood 92:345–347, 1998. discus-
115. Dykstra B, et al: Long-term propagation of distinct hematopoietic sion 352.
differentiation programs in vivo. Cell Stem Cell 1:218–229, 2007. doi: 138. Moore KA, Lemischka IR: Stem cells and their niches. Science
10.1016/j.stem.2007.05.015. 311:1880–1885, 2006. doi: 10.1126/science.1110542.
116. Lemischka IR, Raulet DH, Mulligan RC: Developmental potential and 139. Abkowitz JL, et al: Behavior of hematopoietic stem cells in a large
dynamic behavior of hematopoietic stem cells. Cell 45:917–927, 1986. animal. Proc Natl Acad Sci USA 92:2031–2035, 1995.