Page 145 - Hematology_ Basic Principles and Practice ( PDFDrive )
P. 145

110.e6  Part II  Cellular Basis of Hematology


        230.  Mar  BG,  Amakye  D,  Aifantis  I,  et al: The  controversial  role  of  the   252.  Wadman  I,  et al:  Specific  in  vivo  association  between  the  bHLH
            Hedgehog pathway in normal and malignant hematopoiesis. Leukemia   and  LIM  proteins  implicated  in  human  T  cell  leukemia.  EMBO  J
            25:1665–1673, 2011. doi: 10.1038/leu.2011.143.        13:4831–4839, 1994.
        231.  Bhardwaj  G,  et al:  Sonic  hedgehog  induces  the  proliferation  of   253.  Robb L, et al: Absence of yolk sac hematopoiesis from mice with a tar-
            primitive human hematopoietic cells via BMP regulation. Nat Immunol   geted disruption of the scl gene. Proc Natl Acad Sci USA 92:7075–7079,
            2:172–180, 2001. doi: 10.1038/84282.                  1995.
        232.  Trowbridge JJ, Scott MP, Bhatia M: Hedgehog modulates cell cycle regu-  254.  Shivdasani  RA,  Mayer  EL,  Orkin  SH:  Absence  of  blood  formation
            lators in stem cells to control hematopoietic regeneration. Proc Natl Acad   in  mice  lacking  the T-cell  leukaemia  oncoprotein  tal-1/SCL.  Nature
            Sci USA 103:14134–14139, 2006. doi: 10.1073/pnas.0604568103.  373:432–434, 1995. doi: 10.1038/373432a0.
        233.  Dierks C, et al: Expansion of Bcr-Abl-positive leukemic stem cells is   255.  Warren  AJ,  et al: The  oncogenic  cysteine-rich  LIM  domain  protein
            dependent on Hedgehog pathway activation. Cancer Cell 14:238–249,   rbtn2  is  essential  for  erythroid  development.  Cell  78:45–57,
            2008. doi: 10.1016/j.ccr.2008.08.003.                 1994.
        234.  Zhao  C,  et al:  Hedgehog  signalling  is  essential  for  maintenance  of   256.  Porcher  C,  et al:  The  T  cell  leukemia  oncoprotein  SCL/tal-1  is
            cancer stem cells in myeloid leukaemia. Nature 458:776–779, 2009.   essential for development of all hematopoietic lineages. Cell 86:47–57,
            doi: 10.1038/nature07737.                             1996.
        235.  Gao J, et al: Hedgehog signaling is dispensable for adult hematopoietic   257.  Yamada Y, et al: The T cell leukemia LIM protein Lmo2 is necessary
            stem  cell  function.  Cell  Stem  Cell  4:548–558,  2009.  doi:  10.1016/j.  for adult mouse hematopoiesis. Proc Natl Acad Sci USA 95:3890–3895,
            stem.2009.03.015.                                     1998.
        236.  Hofmann I, et al: Hedgehog signaling is dispensable for adult murine   258.  Robb L, et al: The scl gene product is required for the generation of
            hematopoietic  stem  cell  function  and  hematopoiesis.  Cell  Stem  Cell   all hematopoietic lineages in the adult mouse. EMBO J 15:4123–4129,
            4:559–567, 2009. doi: 10.1016/j.stem.2009.03.016.     1996.
        237.  Merchant AA, Matsui W: Smoothening the controversial role of hedge-  259.  Gottgens  B,  et al:  Establishing  the  transcriptional  programme  for
            hog in hematopoiesis. Cell Stem Cell 4:470–471, 2009. doi: 10.1016/j.  blood:  the  SCL  stem  cell  enhancer  is  regulated  by  a  multiprotein
            stem.2009.05.006.                                     complex containing Ets and GATA factors. EMBO J 21:3039–3050,
        238.  Dar A, et al: Chemokine receptor CXCR4-dependent internalization   2002. doi: 10.1093/emboj/cdf286.
            and  resecretion  of  functional  chemokine  SDF-1  by  bone  marrow   260.  Hall MA, et al: The critical regulator of embryonic hematopoiesis, SCL,
            endothelial and stromal cells. Nat Immunol 6:1038–1046, 2005. doi:   is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage
            10.1038/ni1251.                                       choice in CFU-S12. Proc Natl Acad Sci USA 100:992–997, 2003. doi:
        239.  Ding L, Morrison SJ: Haematopoietic stem cells and early lymphoid   10.1073/pnas.0237324100.
            progenitors occupy distinct bone marrow niches. Nature 495:231–235,   261.  Mikkola  HK,  et al:  Haematopoietic  stem  cells  retain  long-term
            2013. doi: 10.1038/nature11885.                       repopulating  activity  and  multipotency  in  the  absence  of  stem-cell
        240.  Sugiyama T, Kohara H, Noda M, et al: Maintenance of the hemato-  leukaemia SCL/tal-1 gene. Nature 421:547–551, 2003. doi: 10.1038/
            poietic  stem  cell  pool  by  CXCL12-CXCR4  chemokine  signaling  in   nature01345.
            bone  marrow  stromal  cell  niches.  Immunity  25:977–988,  2006.  doi:   262.  Souroullas GP, Salmon JM, Sablitzky F, et al: Adult hematopoietic stem
            10.1016/j.immuni.2006.10.016.                         and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell
        241.  Tzeng  YS,  et al:  Loss  of  Cxcl12/Sdf-1  in  adult  mice  decreases  the   4:180–186, 2009. doi: 10.1016/j.stem.2009.01.001.
            quiescent  state  of  hematopoietic  stem/progenitor  cells  and  alters  the   263.  Aifantis  I,  Raetz  E,  Buonamici  S:  Molecular  pathogenesis  of  T-cell
            pattern  of  hematopoietic  regeneration  after  myelosuppression.  Blood   leukaemia  and  lymphoma. Nat  Rev  Immunol  8:380–390,  2008.  doi:
            117:429–439, 2011. doi: 10.1182/blood-2010-01-266833.  10.1038/nri2304.
        242.  Greenbaum  A,  et al:  CXCL12  in  early  mesenchymal  progenitors  is   264.  Minegishi N, et al: The mouse GATA-2 gene is expressed in the para-
            required for haematopoietic stem-cell maintenance. Nature 495:227–  aortic  splanchnopleura  and  aorta-gonads  and  mesonephros  region.
            230, 2013. doi: 10.1038/nature11926.                  Blood 93:4196–4207, 1999.
        243.  Ding L, Saunders TL, Enikolopov G, et al: Endothelial and perivascular   265.  Tsai  FY,  et al:  An  early  haematopoietic  defect  in  mice  lacking  the
            cells maintain haematopoietic stem cells. Nature 481:457–462, 2012.   transcription  factor  GATA-2.  Nature  371:221–226,  1994.  doi:
            doi: 10.1038/nature10783.                             10.1038/371221a0.
        244.  Spitz  F,  Furlong  EE:  Transcription  factors:  from  enhancer  binding   266.  Tsai  FY,  Orkin  SH:  Transcription  factor  GATA-2  is  required  for
            to  developmental  control.  Nat  Rev  Genet  13:613–626,  2012.  doi:   proliferation/survival of early hematopoietic cells and mast cell forma-
            10.1038/nrg3207.                                      tion, but not for erythroid and myeloid terminal differentiation. Blood
        245.  Wilkinson  AC,  Gottgens  B:  Transcriptional  regulation  of  haema-  89:3636–3643, 1997.
            topoietic  stem  cells.  Adv  Exp  Med  Biol  786:187–212,  2013.  doi:   267.  Minegishi  N,  et al:  Expression  and  domain-specific  function  of
            10.1007/978-94-007-6621-1_11.                         GATA-2 during differentiation of the hematopoietic precursor cells in
        246.  Kataoka  H,  et al:  Etv2/ER71  induces  vascular  mesoderm  from   midgestation mouse embryos. Blood 102:896–905, 2003. doi: 10.1182/
            Flk1+PDGFRalpha+  primitive  mesoderm.  Blood  118:6975–6986,   blood-2002-12-3809.
            2011. doi: 10.1182/blood-2011-05-352658.          268.  Hsu AP, et al: Mutations in GATA2 are associated with the autosomal
        247.  Lee D, et al: ER71 acts downstream of BMP, Notch, and Wnt signaling   dominant  and  sporadic  monocytopenia  and  mycobacterial  infection
            in blood and vessel progenitor specification. Cell Stem Cell 2:497–507,   (MonoMAC) syndrome. Blood 118:2653–2655, 2011. doi: 10.1182/
            2008. doi: 10.1016/j.stem.2008.03.008.                blood-2011-05-356352.
        248.  De Val S, et al: Combinatorial regulation of endothelial gene expression   269.  Vinh  DC,  et al:  Autosomal  dominant  and  sporadic  monocytope-
            by ets and forkhead transcription factors. Cell 135:1053–1064, 2008.   nia  with  susceptibility  to  mycobacteria,  fungi,  papillomaviruses,
            doi: 10.1016/j.cell.2008.10.049.                      and  myelodysplasia.  Blood  115:1519–1529,  2010.  doi:  10.1182/
        249.  Lancrin  C,  et al: The  haemangioblast  generates  haematopoietic  cells   blood-2009-03-208629.
            through a haemogenic endothelium stage. Nature 457:892–895, 2009.   270.  Bigley V, et al: The human syndrome of dendritic cell, monocyte, B and
            doi: 10.1038/nature07679.                             NK lymphoid deficiency. J Exp Med 208:227–234, 2011. doi: 10.1084/
        250.  Osada H, Grutz G, Axelson H, et al: Association of erythroid transcrip-  jem.20101459.
            tion  factors:  complexes  involving  the  LIM  protein  RBTN2  and  the   271.  Dickinson RE, et al: Exome sequencing identifies GATA-2 mutation as
            zinc-finger  protein  GATA1.  Proc  Natl  Acad  Sci  USA  92:9585–9589,   the cause of dendritic cell, monocyte, B and NK lymphoid deficiency.
            1995.                                                 Blood 118:2656–2658, 2011. doi: 10.1182/blood-2011-06-360313.
        251.  Valge-Archer VE, et al: The LIM protein RBTN2 and the basic helix-  272.  Spinner  MA,  et al:  GATA2  deficiency:  a  protean  disorder  of  hema-
            loop-helix protein TAL1 are present in a complex in erythroid cells.   topoiesis, lymphatics, and immunity. Blood 123:809–821, 2014. doi:
            Proc Natl Acad Sci USA 91:8617–8621, 1994.            10.1182/blood-2013-07-515528.
   140   141   142   143   144   145   146   147   148   149   150