Page 1847 - Hematology_ Basic Principles and Practice ( PDFDrive )

Chapter 107 Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies 1643

TABLE Comparison of Double-Unit Cord Blood Transplantation With Adult Donor HSC Transplantation—cont’d
107.3
CI (%) of
Neutrophil
Engraftment
Age Days to
Median Neutrophil III–IV
Graft (range), in Conditioning Engraftment, II–IV Acute Acute Chronic
Reference (Patients n) years (Patients n) Median (range) GVHD GVHD GVHD TRM Relapse Survival
Liu et 70 CBT 23 MA 19 (13–32) 40% 4% Overall 34.2% at 6 11.9% at DFS 55% at
al 109 (16–46) TBI-based 20.7% months 3 years 3 years
(93%) Extensive 35.7% at 2
Bu-based (7%) 3.4% years
115 MRD 32 MA 12 (10–18) 15% 10% Overall 8.7% at 6 16.2% at DFS 60% at
(59% PB, (16–58) TBI-based 42.2% months 3 years 3 years
50% PB (26%) Extensive 25.3% at 2
+ BM, Bu-based 14.6% years
6% BM) (74%)
Marks et 116 CBT 25 MA 25 days 27% 9% 39% at TRM 42% at 22% at OS: 44% at
al 102 (16–59) TBI-based 57% at day 3 years 3 years 3 years 3 years
(94%) +28
Bu-based (4%) 91% at day
+60
546 8/8 32 MA 95% at day 47% 16% 42% at 31% at 3 25% at OS: 44% at
matched (16–59) TBI-based +28 3 years years 3 years 3 years
(33.3% (89%) 97% at day
BM, Bu-based +60
66.6% (11%)
PB)
140 7/8 33 MA 96% at day 41% 24% 45% at 39% at 3 28% at 3 OS: 43% at
matched (16–59) TBI-based +28 3 years years years 3 years
(40% (89%) 97% at day
BM, Bu-based +60
60% PB) (10%)
Reduced Intensity Regimens
Majhail 43 CBT 59 Flu/Cy/TBI 89% at day 49% 17% at 28% at day PFS 34% at
et al 88 (55–69) (84%) +42 1 year +180 3 years
ATG (40%) OS: 34% at
3 years
47 MRD 58 Flu/Cy/TBI 100% at day 42% 40% at 23% at day PFS: 30% at
(55–70) (70%) +42 1 year +180 3 years
ATG (13%) (p = .02) OS: 43% at
3 years
Brunstein 50 CBT 58 Flu/Cy/TBI 15 days 40% 21% 25% at 24% at 31% at OS: 54% at
et al 89 (16–69) (4–47) 1 year 1 year 1 year 1 year
94% at day PFS: 46% at
+56 1 year
50 48 (7–70) Flu/Cy/TBI 16 days 32% 0% 13% at 7% at 45% at OS: 62% at
Haplo-BM (12–83) 1 year 1 year 1 year 1 year
96% at day PFS: 48% at
+56 1 year
Ponce et 75 DCBT 37 53 MA 93% 43% 28% 25% (2 20% at 55% (2
al 78 (<1–66) 22 NMA MA (24 days) years) 2 years years)
No T-depletion NMA (10 days)
108 RD 47 89 MA 100% Unmodified Unmodified 15% at 2 19% 66%
(<1–71) 19 NMA MA (11 days) 27%, TCD 31%, years (unmodified)
66% NMA (11 days) 8% TCD and 19%
T-depletion 12% (TCD) at 2
years
184 URD 48 (1–71) 156 MA 97% Unmodified Unmodified 27% at 2 9% 55%
28 NMA MA (11 days) 31%, TCD 44%, years (unmodified)
68% NMA (10 days) 12% TCD and 24%
T-depletion 19% (TCD) at 2
years
Continued