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1164 Part IX: Lymphocytes and Plasma Cells Chapter 75: Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production 1165

Cenromeric
3D-7 1D-8 1D-43 1D-42 2D-10 3D-11 1D-12 1D-13
5' 200 kb

2D-14 3D-15 1D-16 1D-17 6D-41 2D-18 2D-19 3D-20 3D-20 1D-22 3D-23 2D-24 3D-25 2D-26 3D-27 2D-28 2D-26 2D-30
400 kb

3D-31 1D-32 1D-33 3D-34 1D-35 2D-36 1D-37 2D-38 10-39 2D-40 2-40 1-39 2-38 1-37 2-36 1-35 3-34 1-33
κ ~800 kb 1 400 kb

1-32 3-31 2-30 2-29 2-28 1-27 2-26 3-25 2-24 2-23 1-22 6-21 3-20 2-19 2-18 1-17 1-16 3-15 2-14
1 600 kb

1-13 1-12 3-11 2-10 1-9 1-8 3-7 1-6 1-5 2-4 7-3 5-2 4 1 J1 to 5 C Telomeric
3' 1 820 kb
Enhanoers

Centromeric (IV)-66-1 (IV)-65 (IV)-64
BCRL2 (I)-70 4-69 (I)-68 10-67 (V)-66
5' 200 kb
C (IV)-59 TGFb1 (IV)-53
(I)-63 1-62 8-61 4-60 (V)-58 6-57 (I)-56 11-55 10-54 VpreB
800 kb
5'0Y11.1 5-52 1-51 1-51 9-49 5-48 1-47 7-46 5-45 1-44 7-43 (I)-42 1-41 1-40 5-39 (1)-38 5-37 1-36 7-35

λ B 800 kb
5'0Y11.1 3'0Y11.1 2-34 2-33 3-32 3-31 (VII)-41-1 3-30 BCRL4 POM121 GGT GGT rel 3-29 2-28 3-27 3-26 (VI)-25-1 3-25

800 kb

A (VI)-22-1 J-C-CLUSTER Telomeric
3-24 2-23 3-22 3-21 (I)-20 3-19 2-18 3-17 3-16 3-15 2-14 3-13 3-12 2-11 3-10 3-9 2-8 3-7 3-6 2-5 3-4 4-3 3-2 3-1 12 34 56 7
3' 1 050 kb
Enhancer

Figure 75–5. Immunoglobulin light-chain gene complexes. The top panel depicts the κ light-chain gene complex on chromosome 2p11-12. The
blue box represents functional IGLC gene. The IGKJ gene segments are indicated by yellow lines labeled “J1 to 5.” The κ light-chain enhancers are repre-
sented by light blue circles. IGKV functional genes, pseudogenes, and open-reading frames are indicated by green, red, and yellow boxes, respectively.
The IGKV genes of the p region are designated by a number for the subgroup, followed by a hyphen and a number for the localization from 3′ to
5′ in the locus. The IGKV genes of the d region are designated by the same numbers as the corresponding genes in the p region, with the letter D
added. Arrows show the IGKV genes whose orientation is opposite to that of the IGKJ gene segments. The bottom panel depicts the λ light-chain
gene complex on chromosome 22q11.2. The blue boxes represent functional IGLJ and IGLC gene segments, whereas the blue open boxes represent
IGLJ and IGLC pseudogenes. IGLV functional genes, pseudogenes, and open-reading frames are indicated by green, red, and yellow boxes, respectively.
IGLV pseudogenes that could not be assigned to subgroups with functional genes are represented by red boxes and designated by a roman number
between parentheses, corresponding to the clans, followed by a dash and a number for the localization from 3′ to 5′ in the locus. The IGLV genes are
organized into three clusters, designated A, B, and C, which are indicated to the left of each cluster. Unrelated pseudogenes are represented by purple
open boxes. The λ light-chain enhancer is represented by a light blue circle. Colors are according to IMGT color menu for genes. (Used with permission of
Marie-Paule Lefranc. IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org.)

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