Page 1883 - Williams Hematology ( PDFDrive )

1858 Part XII: Hemostasis and Thrombosis Chapter 112: Platelet Morphology, Biochemistry, and Function 1859

TABLE 112–4. Important Platelet Surface Proteins
M r
Platelet
Chain Integrin VLA Des- CD † Non-
†
Gene Family Common Name Designation Designation ignation Designation Reduced Reduced
Integrin Fibrinogen/receptor α β α β -CD41a α IIb 145,000 α α 125,000
IIb
IIb 3
IIb 3
α -CD41b β 3 90,000 α β 23,000
IIb
IIb
β -CD61 114,000
3
Collagen receptor GPla/IIa α β VLA-2 α -CD49b α 150,000 148,000
2 1 2 2
β -CD29 β 138,000
1 1
Fibronectin receptor CPIc*/IIa α β VLA-5 α -CD49e α 140,000 148,000
5 1 5 5
β -CD29 β 138,000
1 1
Laminin receptor GPlc/IIa α β VLA-6 α -CD49f α 140,000 148,000
6 1 6 6
β -CD29 β 138,000
1 1
Vitronectin receptor α /GPIIIa α β α -CD51 α v 150,000 α v 125,000
v 3
v
v
β -CD61 β 90,000 α 25,000
3 3 v
114,000
Leucine-rich von Willebrand GPlb/Ix Ib/Ix-CD42 GPIb 170,000 GPIbα 145,000
repeat factor receptor Ib/α-CD42b GPIbβ 22,000
glycoproteins Ib/β-CD42c
Ix-CD42a GPIX 17,000 17,000
GPV GPV 82,000 82,000
Immunoglob- PECAM-I CD31 130,000
ulin family Fcγ-RII CD32 40,000
cell adhesion
modecules HLA-Class 1
ICAM-2 CD102 59,000
GPVI 62,000 65,000
IAP CD47 50,000
Selectins P-Selectin (GMP 140; CD62P 140,000
PADGEM)
Tetraspanins p24 CD9 24,000
CD63
PETA-3 CD151 27,000
Lamp 3 (granulophysin) CD63 53,000
Miscellaneous GPIV CD36 88,000
CLEC-2 CD94
TLR(1-6)

Lamp 1 CD107a 110,000
Lamp 2 CD107b 120,000
67 kDa Laminin 67,000
receptor
ADP P2X1 receptor 70,000
Leukosialin, sialophorin CD43 90,000
Seven trans- PAR-1 70,000
membrane PAR-4
domain (G
protein-linked) Thromboxane A 2 55,000
receptor
α -Adrenergic receptor 64,000
2
Vasopressin receptor 125,000

ADP P2Y receptor
1
ADP P2Y receptor
12
Serotonin 5-HT2A 53,000
Fib, fibrinogen; Fn, fibronectin; GP, glycoprotein; HLA, human leukocyte antigen; IAP, integrin-associated protein; ICAM, intercellular adhesion
molecule; lamp, lysosome-associated membrane protein; PAR, protease-activated receptor; PECAM, platelet-endothelial cell adhesion mole-
cule; PSGL-1, P-selectin glycoprotein ligand-1; TSP, thrombospondin; TX, thromboxane; Vn, vironectin; vwf, von Willebrand factor.

Kaushansky_chapter 112_p1829-1914.indd 1858 17/09/15 3:29 pm