Page 1884 - Williams Hematology ( PDFDrive )

1858 Part XII: Hemostasis and Thrombosis Chapter 112: Platelet Morphology, Biochemistry, and Function 1859

Phos- Molecules on
Carbo- phory- Chromo- Platelet Platelet Surface
Amino Acids hydrate Lipid lated some Ligands Specific Function (S) or Internal (I)
α 1039 + – – 17 Fib, VWF, Fn, Vn, ?TSP + Adhesion, aggregation, (S)80,000
IIb
+ protein trafficking (I)40,000
β 762 + – + 17
3
α 1152 5 Collagen – Adhesion (S)1000
2
β 778 10 –
1
α 1008 12 Fn – Adhesion (S)1000
5
β 778 10
1
α 1067 2 Laminin – Adhesion (S)1,000
6
β 778 10
3
α 1048 2 Vn, Fib, VWF, Fn, ?TSP, – ?Adhesion, (S)100
v
Osp ?Protein trafficking
GPIIIa 762 + – 17
GPIbα610(8)* + – – 1 VWF, Thrombin +? Adhesion (high shear), (S)25,000
GPIbβ181(1)* + + + 22 +? ?thrombin activation (S)25,000
GPIX 160(1)* + + 3 +? (S)25,000
GPV 544(15)* + + + 3 +? (S) 12,500
PECAM-1 738 + ? + 17 Heparin – ?Adhesion (S) 8000
FcγRII 324 + + 1 Immune complexes – Immune complex binding (s) ~1000
HLA + 6 – Histocompatibility (S)
ICAM-2 274 17 LFA-1 – Platelet-leukocyte adhesion (S) 2600
GPVI 316 + – ? Collagen + Activation (S) ~2000
IAP 287 + 3 TSP – Activation
P-Selectin 830 + + + 1 Sialyl-le x Platelet-leukocyte adhesion (I) 20,000
PSGL-1
CD9 228 + ? – Activation (S) 40,000

CD151 253 + – – 11 ? – Activation (I) ~2000
Lamp 3 238 + (I) 10,000
GPIV 471 + + 7 Collagen, TSP – Adhesion (S) 20,000
CLEC-2 229 + + 12 Podoplanin – adhesion/activation
TLR Pathogen- – activation
associated molecular
patterns
Lamp 1 389 + 13 ? – ? (I) 1200
Lamp 2 381 + X ?
67 kDa ?295 X Laminin – Adhesion

P2X 399 + 17 ATP, ADP – Activation (S) 13–130
1
CD43 400 + + 16 ICAM-1 – Adhesion
PAR-1 425 5 Thrombin – Activation (S) ~1800
PAR-4 385 + + 19 Thrombin – Activation
TXA 343 19 PGH /thromboxane – Activation ~200
2
2
A
2
α -Adrenergin 10 Epinephrine – Activation ~250
2
450
Vasopressin ?x Vasopressin – Activation ~75
418
P2Y 373 + 3 ADP – Activation
1
P2Y 342 3 ADP + Activation
12
5-HT2A + + 13 Serotonin – activation
*Number of leucine-rich repeats.
†CD, cluster of differentiation (see Chap. 15); VLA, very-late antigen.

Kaushansky_chapter 112_p1829-1914.indd 1859 17/09/15 3:29 pm