Page 217 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHAPTER 12 T-Cell Activation and Tolerance 196.e1

MULTIPLE-CHOICE QUESTIONS

1. Individual mutations in T-cell signaling proteins can lead to 3. In the clinic, monoclonal antibodies directed against T cell
immune deficiency, dysregulation, or lymphocyte proliferation. signaling coinhibitory molecules are proving to be efficacious
Among the following molecules, which one is primarily associ- against cancers. Which of the following is a coinhibitory
ated with lymphocyte hyperproliferation and an increased molecule that where blockade has proven to be helpful in
risk of autoimmunity? tumor immunotherapy?
A. ZAP-70 A. CTLA-4
B. SLP-76 B. CD28
C. CD45 C. OX40
D. CD95 D. CD3
2. Which of the following are mechanisms of central tolerance
A. Immune privilege
B. Treg regulation
C. Clonal deletion/AIRE
D. Anergy