Page 303 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 19 Host Defenses in Skin 283.e1

MULTIPLE-CHOICE QUESTIONS

1. Pembrolizumab and nivolumab are neutralizing antibodies C. Dermatitis herpetiformis
directed at the programmed death ligand type 1 (PD-L1) and D. Hyper-IgE syndrome (HIES)
ipilimumab is an antibody that neutralizes cytotoxic T E. Pemphigus
lymphocyte antigen-4 (CTLA-4). They are used to treat which 4. In a normal healthy individual, which of the following has
of the following cutaneous malignancies? the largest number of lymphocytes?
A. Basal cell carcinoma A. Blood
B. Fibrosarcoma B. Brain
C. Kaposi sarcoma C. Kidney
D. Melanoma D. Liver
E. Sebaceous gland carcinoma
E. Skin
2. Skin is a rich source of cytokines and chemokines. Which
cell type does not produce them in skin? 5. Which of the following is true about epidermal Langerhans
A. Fibroblasts cells?
B. Keratinocytes A. They possess a specialized organelle called the Birbeck
C. Mast cells granule.
D. Melanocytes B. They are a type of myeloid dendritic cell (DC).
E. All of the above produce cytokines in the skin C. Following cutaneous exposure to danger signals, they
extrude their processes to capture external antigens.
3. Cathelicidins are antimicrobial peptides that are produced D. After cutaneous antigen exposure, they migrate to draining
by skin. They have been implicated in which of the following lymph nodes.
diseases? E. All of the above are true.
A. Atopic dermatitis
B. Cutaneous T-cell lymphoma