Page 592 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 40 Autoantibody-Mediated Phenocopies of Primary Immunodeficiency Diseases 567.e1

M u LTIPLE-CHOICE Q u ESTIONS

1. High-titer, neutralizing autoantibodies against which cytokine 3. A previously healthy HIV-negative 34-year-old woman
is commonly seen in autoimmune polyendocrinopathy presented with few days of fever, headache, neck pain, and
candidiasis ectodermal dystrophy (APECED) syndrome? vomiting. She also reported progressively increasing exertional
A. Interferon (IFN)-α dyspnea since the past 6 months. Lumbar puncture showed
B. IFN-γ increased opening pressure. Cerebrospinal fluid (CSF) analysis
C. Granulocyte macrophage–colony-stimulating factor revealed increased white blood cell (WBC) count with lym-
(GM-CSF) phocytic predominance, low glucose, and elevated protein. The
D. Interleukin (IL)-6 CSF cryptococcal antigen was positive, and the culture grew
Cryptococcus neoformans. Brain magnetic resonance imaging
2. A 45-year-old female who moved from Taiwan to the United
States at the age of 20 years presents with disseminated (MRI) was normal. Chest computed tomography (CT) showed
Mycobacterium abscessus with pulmonary and bone lesions ground-glass opacities in both lungs. Bronchoalveolar lavage
and cervical lymphadenopathy. Autoantibodies to which (BAL) revealed periodic acid-Schiff (PAS)–positive material
cytokine may be associated with her disease? on cytology, consistent with a diagnosis of pulmonary alveolar
A. IL-17 proteinosis (PAP). Autoantibodies against which cytokine may
B. IL-22 be associated with her manifestations?
C. IFN-α A. GM-CSF
D. IFN-γ B. IL-6
C. G-CSF
D. Erythropoietin
E. IFN-γ