Page 93 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPter 4 Antigen Receptor Genes, Gene Products, and Coreceptors 77.e1

MUL t IPL e -CH o IC e QU e S t I on S

1. The mechanism that generates the greatest diversity in 3. Signal transduction through the B-cell receptor (BCR) is
immunoglobulins (Igs) is: inhibited by:
A. Combinatorial V(D)J rearrangement A. CD3ζ
B. Combinatorial H and L chain association B. CD19
C. N nucleotide addition C. CD21
D. Somatic hypermutation (SHM) D. CD22
E. Class-switch recombination (CSR) E. CD81
2. The mechanism that generates the greatest diversity in T-cell 4. Signal transduction through the TCR is enhanced by:
receptors (TCRs) is: A. FcγRII
A. Combinatorial V(D)J rearrangement B. CD28
B. Combinatorial H and L chain association C. Cytotoxic T lymphocyte antigen-4 (CTLA-4)
C. N-nucleotide addition D. Programmed death 1 (PD-1)
D. SHM E. CD79a
E. CSR