Page 1764 - Hall et al (2015) Principles of Critical Care-McGraw-Hill

CHAPTER 125: Critical Care Pharmacology 1233
TABLE 125-9 Cytochrome P450 Classes: Selected Substrates, Inhibitors,
and Inducers
TABLE 125-9 Cytochrome P450 Classes: Selected Substrates, Inhibitors, Isozymes Substrates Inhibitors and Inducers
and Inducers
Mefenamic acid Rifabutin
Isozymes Substrates Inhibitors and Inducers
(S)-Mephenytoin Rifampin
CYP1A2 Amitriptyline Inhibitors (R)-Mephobarbital
Antipyrine Amiodarone Naproxen
Caffeine Cimetidine Nelfinavir
Clomipramine Ciprofloxacin (all Omeprazole
quinolones)
Phenytoin
Clozapine Ticlopidine
Piroxicam, other oxicam drugs
Cyclobenzaprine Inducers
Progesterone
Dapsone (minor) Broccoli, Brussels sprouts
Propranolol
Estradiol Char-grilled meats
Rosiglitazone
Haloperidol Cigarette smoking
Tolbutamide
Imipramine (also 2C9 & 3A4) Insulin
Torsemide
Mexiletine Nafcillin
(S)-Warfarin
Naproxen Omeprazole Zafirlukast (2C9)
Ondansetron (minor) CYP2D6 Amitriptyline Inhibitors
Propranolol Amphetamines Amiodarone
Tacrine Carvedilol Cimetidine
Theophylline Chlorpromazine Fluconazole
Warfarin (minor) Clomipramine (major) Fluoxetine
Verapamil Clonazepine (minor) Fluphenazine
Zolmitriptan Codeine Fluvoxamine
CYP2B6 Bupropion Inhibitors Debrisoquine Haloperidol
Cyclophosphamide Orphenadrine Desipramine Ketoconazole
Efavirenz Thiotepa Dextromethorphan Paroxetine
Ifosfamide Ticlopidine Dihydrocodeine Propafenone
Methadone Inducers Dolasetron Quinidine
Phenobarbital Flecainide Quinine
Phenytoin Fluoxetine Ritonavir
Rifampin Haloperidol Sertraline
CYP2C Amitriptyline Inhibitors Hydrocodone Inducers
Carbamazepine Amiodarone Imipramine Dexamethasone
Celecoxib Chlorguanide Lidocaine Rifabutin
Chlorguanide Fluconazole Loratadine (minor) Rifampin
Clomipramine (minor) Fluvastatin Metoclopramide
Cyclophosphamide Fluvoxamine Metoprolol
Diazepam Isoniazid Mexiletine
Diclofenac Itraconazole Nortriptyline
Glimepiride Ketoconazole Ondansetron
Glipizide Lovastatin Penbutolol
Glyburide Omeprazole Perphenazine
Ibuprofen Ritonavir Phenacetin
Ifosfamide Simvastatin Propafenone
Imipramine (minor) Sulfaphenazole Propranolol
Indomethacin Inducers Risperidone
Irbesartan Carbamazepines Ritonavir (minor)
Lansoprazole (most proton Norethindrone Tamoxifen
pump inhibitors) Phenobarbital Thioridazine
Losartan Prednisone Timolol (Continued)

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