Page 339 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 17 ■ Hemoglobinopathies and Thalassemias 323

Sickle Cell Trait

m m
A x m % k Am z .

H S. T , H S A. S k I m m ;

- m m q

m m m , P. alciparum, z m m . G

m . S k m m m . S k m m . T α

, - m , ζ ,

m k . L x m m . m m -

m k (AS) m m , , α- q .

m H A. AS k O m m , , -

SS . A , AS - m -α m m . T γ

z k m m . I m

x . α β m ,

m m , m .

m , k , A m

m k . E m

% % m q . O -

k H S. C

m m k m . T

m , (

, ), , , . A m m

.

. A m q

, f

NOTE: This is a good time to complete Review Questions mRNA

related to the preceding content. . A m m

x

. A m m

HALASSEMIA m
; mRNA m -

Demographics
. A ,
T m m, q m m

m , -

m x x . Pathophysiology

A mm

m . I , H E–β - T m z

m H H m j

m . W , H E–β m m m m . I α m ,

m q m . T α- -

H E % m m H H

S A . I N Am , m . T m β m

. α T m , x m α- , -

, z m x β-

. H H, H H– (CS), . S RNA m m

m z α m m - m β m

. C H H RNA . T f RNA

m - .

m H H H H–CS. H m z

α m , , m mm b Thalassemia

.
β T m m mm - -

Etiology . M m β m
m , , m -

T m m β- . M

. T m β- k

m ( . ., H S H C) m β- ,