Page 341 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 17 ■ Hemoglobinopathies and Thalassemias 325

H F. T H A x m m

β- . . PCR m m

H z β m m k . U m m

m m m . m . PGD x HLA -

O MCV, m . T

H A , m . m m m

. mm z SCD, m-

k , m . m m . S m

m .

Prenatal Diagnosis
New born Screening
P β m

m H , m

DNA PCR m - β m m j . I

. L , m U S , m α- m

m m - , H H H H CS H E

. T m m - m z .

m - m m

- - (β/α) . x m

B , m m U S .

m m - k I m , m

. P m (PGD) m m HPLC IE

m z , - q m k m -
m . I H H

, q

Summary of Selected Laboratory H B ’

TABLE 17.4 x q - -
Findings in Hemoglobinopathies
. P m

Disorder Test Result m .
I m , m

SCD Hemoglobin Decreased q -

PCV Decreased m . S -

Erythrocyte count Decreased m β
m m j m hereditary m -
Hb S Signi cantly (HPFH), H Eβ m m H EE, H H

increased m α m . G m m

Hb A Decreased

Hb F Increased .

Sickle cell trait Hemoglobin Normal
Treatm ent

PCV Normal
M m m -

Erythrocyte count Normal m . T m

Hb S Increased m m

Hb A Slightly decreased m
x . I m ,
Hb F Normal or slightly q

increased
m m -

Homozygous β Hemoglobin Decreased m. m m, m

thalassemia . T

PCV Decreased :

Erythrocyte count Decreased ■ ( N Am

Hb S Negative )

Hb A Signi cantly ■ x m

decreased ■ x ( )

Hb F Increased T m x m

m
PCV packed cell volume.
,
’ q .