Page 340 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

324 PART 4 ■ Erythrocyte Disorders

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TABLE 17.3 b Thalassemia Types

Phenotype Clinical Descriptions

Thalassemia minor Mild anemia, microcytosis, abnormal erythrocyte morphology, splenomegaly

(Thalassemia trait)

Thalassemia intermedia Moderate anemia and ineffective erythropoiesis, microcytosis, abnormal erythrocyte morphol-

ogy, splenomegaly, iron overload, not transfusion dependent

Thalassemia major Severe anemia caused by ineffective erythropoiesis, transfusion dependent, organ

(Cooley’s anemia) damage (heart, liver, etc.) secondary to iron overload, extramedullary erythropoiesis,

hepatosplenomegaly