Page 746 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )
P. 746
730 Glossary
coproporphyrin – a porphyrin ormed in the intestine rom bili- ense granules – a type o granule ound in platelets, megakaryocytes
rubin. Abnormal amounts may be ound in the urine in some eoxyhemoglobin – reduced hemoglobin
orms o anemia eoxynucleoti e – components o DNA (phopshate, sugar and an
cor bloo – blood obtained rom the umbilical vessels at birth organic base such as A P, C P, G P, P) that are required by
correcte reticulocyte count – a mathematical adjustment o the the DNA enzyme, DNA polymerase, or DNA synthesis
reticulocyte count to account or variations caused by erythro- eoxyribonucleic aci – DNA
cyte quantity DH – diversity region o the immunoglobulin heavy chain gene locus
Coulter principle – a method o cell counting and volumetric sizing iabetes mellitus – a disorder o carbohydrate metabolism caused
based on the detection and measurement o changes in electri- by an insu ciency o insulin
cal resistance produced by a particle, suspended in a conductive iagnosis – determination o the nature o a disorder or disease
liquid, traversing a small aperture ialysate – the soluble materials and uids (e.g., water) that pass
counterstain – a stain used to enhance a previously applied primary through a semipermeable membrane
stain ialysis – the passive process o movement o soluble substances
CPPD – see calcium pyrophosphate dihydrate and water molecules through a semipermeable membrane
cryoglobulin – a serum globulin that precipitates, gels, or crystal- Diamon -Black an anemia – an inherited (congenital) orm o
lizes spontaneously at low temperatures. May be ound in mul- pure red blood cell aplasia
tiple myeloma and collagen disease iape esis – amoeboid movement o cells
crystalline inclusions – rod-shaped deposits o IgG i eoxy metho (Sanger’s metho ) – a classic molecular assay
CSF – (A) re ers to colony-stimulating actor, a speci c glycoprotein method
macromolecule that stimulates the growth o granulocytes and i usion – the movement o a substance rom an area o high con-
macrophage cells; (B) an abbreviation or cerebrospinal uid centration to an area o low concentration
curve- tting – in computerized automated instruments, the instru- igital cell morphology – an digital electronic orm o cell recognition
ment’s computer process o tting a log-normal curve to the isin ection – a method to remove or reduce in ectious organisms
platelet raw data rom inanimate objects such as table tops
cytochemical stains – staining reactions that produce a colored pre- ispersion – scattered
cipitate rom a speci c insoluble compound in a cell isseminate intravascular coagulation (DIC) – this is a serious
cytochemistry – the identi cation o speci c types o molecules in a cell coagulation disorder that consumes platelets and blood coagula-
cytogenetic analysis – the examination o the chromosomes o a tion actors. It is an example o a major breakdown o the hemo-
nucleated cell static mechanism that occurs when the procoagulant actors
cytogenetics – the branch o genetics concerned with the cellular outweigh the anticoagulant system
elements o heredity iverticulitis – in ammation o the small blind pouches that orm
cytokines – soluble actors secreted by -lymphocyte populations in the lining or wall o the colon
cytokinesis – cytoplasmic division during cellular division (mitosis) DNA – deoxyribonucleic acid
cytological – re ers to cells Döhle bo ies (Amato bo ies) – abnormal inclusion bodies that
cytology – the study o cells appear as light-blue–staining vacuoles predominantly in neutro-
cytomegalovirus in ection – a herpes amily virus that can cause phils in viral diseases and other toxic conditions
congenital in ections in the newborn and a clinical syndrome Down’s syn rome – a chromosomal abnormality. Previously
resembling in ectious mononucleosis re erred to as mongolism
cytore uction – decreasing the number o cells Downey cells – an early classi cation system o certain orms o
variant lymphocytes. Downey I types have many vacuoles in the
D cytoplasm; Downey II types resemble plasma cells; Downey III
d- imer – a molecular orm encountered in excess in disseminated types are an immature orm o lymphocyte
intravascular coagulation (DIC) DPG – diphosphoglycerate (2,3-DPG) combines with the beta
e nitive hematopoiesis – speci cally committed blood cell lines chains o deoxyhemoglobin and diminishes the molecule’s a n-
egmacytes – an abnormal type o red blood cell ity or oxygen
egranulation – the loss o granules such as in the basophil when repanocytes – an abnormal red blood cell orm
an antigen binds to two adjacent IgE antibody molecules located rif – a statistical observation o movement in a speci c direction
on the sur ace o mast cells away rom a measured point on a quality control chart
eletion – a chromosomal aberration in which a segment o a chro- rumsticks – an appendage o nuclear material attached to the nucleus
mosome is lost o a segmented neutrophil. May be seen in some cells in women
elta check(s) – a quality assurance/quality control initiative that DsDNA – double-stranded DNA
monitors a patient’s results or signi cant dif erences between yscrasia – an abnormal or pathological condition o the blood
repeat testing results yserythropoiesis – de ective red blood cell maturation
elta granule – a type o storage granule ound in the mature platelet yserythropoietic anemia – a condition o red cell development
e novo – a newly presented, primary case o a disorder or disease because o abnormal red blood cell development
enaturation – the process o treating a protein with agents such as ysgranulopoiesis – de ective white blood cell maturation
heat or acid and causing it to lose its native properties because o ysmegakaryocytopoiesis – a condition o platelet development
disruption o secondary and tertiary bonding such as hydrogen because o abnormal megakaryocytic development
bonds ysmegapoiesis karyocyte – de ective platelet maturation
enature DNA – double-stranded helix separates into two sin- ysplasia – (adj. dysplastic) abnormal development (e.g., de ective
gle strands, breaking hydrogen bonds; caused by changes in cellular development). Abnormal cytological eatures and tissue
temperature, pH, or nonphysiological concentrations o salt, organization, o en is a premalignant change
detergents, or organic solvents yspnea – di culty in breathing
