Page 74 - B.Tech Biotech Curriculum and Syllabus R2017 - REC

Department of BIOTECHNOLOGY, REC

• Be able to understand the significance of food processing
• Expertise in the concept of safe food.
• To characterize different type of food hazards, physical, chemical and biological in the industry and food
service establishments
• To be aware of the regulatory and statutory bodies in India and the world

TEXTBOOOKS
1. Sivasankar, B. ―Food Processing & Preservation‖, Prentice Hall of India, 2002.
2. Khetarpaul, Neelam, ―Food Processing and Preservation‖, Daya Publications, 2005.
3. Mehta, Rajesh and J. George ―Food Safety Regulation Concerns and Trade : The Developing Country
Perspective‖. Macmillan, 2005.

REFERENCES
1. Potter, Norman N., Hotchkiss, Joseph H. (1995), Food Science, 5th Ed. Springer US
2. Manay, S.; Shadaksharaswami, M., (2004). Foods: Facts and Principles, 4th Ed. New Age Publishers.
3. B. Srilakshmi., (2002), Food Science, New Age Publishers.
4. Meyer, (2004). Food Chemistry.New Age Publishers.
5. Deman JM. (1990) Principles of Food Chemistry. 2nd ed. Van Nostrand Reinhold, NY
6. Ramaswamy H and Marcott M. (2005), Food Processing Principles and Applications. CRC Press.
7. Lightbourne, Muriel ―Food Security, Biological Diversity and Intellectual Property Rights‖ Ashgate, 2009.

BT17E65 CANCER BIOLOGY L T P C
3 0 0 3

OBJECTIVES:
 To enable the students to know cell cycle dysregulation in cancer and various stages of
carcinogenesis.
 To learn about the molecular basis of cancer and new treatment options for cancer patients

UNIT I FUNDAMENTALS OF CANCER BIOLOGY 9
Definition types – benign, malignant tumors, properties, grading, stages, regulation of cell cycle, mutations
that cause changes in signal molecules, signalling pathways – growth factors, G proteins, Wnt, JAK-STAT,
TGF-β, PI3K/AKT, intrinsic and extrinsic apoptotic pathways, heredity and cancer.

UNIT II PRINCIPLES OF CARCINOGENESIS 12
Carcinogenesis – Theroies of carcinogenesis, classification and metabolism of chemical carcinogens
mechanism of chemical carcinogenesis, identificator of carcinogens, radiations and cancer – UV, ionising
radiations – Xray, nuclear, microwave etc, DNA damge due to chemicals & radiations and DNA repair
mechanisms, infections agents and cancer – RNA, DNA virus and carcinogenesis.

UNIT III PRINCIPLES OF MOLECULAR CELL BIOLOGY OF CANCER 9
Molecular cell biology of cancer, oncogenes – identification, classification and activation of proto oncogenes
to oncogenes, tumour suppressor genes – caretaker and gate keeper genes, 2 hit hypothesis, loss of
heterozygosity, APC, CDKN2A, PTEN, Rb, Smad4, TGFβ, P53 and BRCA – Telomeres and Telomerases,
Hall marks of cancer.

UNIT IV PRINCIPLES OF CANCER METASTASIS 6
Clinical significance of invasion, heterogeneity of metastatic phenotype, metastatic cascade, angiogenesis,
basement membrane disruption, three step theory of invasion, proteinases and tumour cell invasion – MMPs,
cadherins integrins, Rho GTPase & HGf in cancer metastasis, metastatic suppressors.

Curriculum and Syllabus | B.Tech. Biotechnology | R2017 Page 74