Page 69 - B.Tech Biotech Curriculum and Syllabus R2017 - REC

Department of BIOTECHNOLOGY, REC

 knowledge about the host defense strategy against pathogens and bacterial defense strategies.
 Familiar with the molecular mechanism of virulence and the ability to perform the cause of bacterial
infections.
 Study the basic knowledge about the host pathogen interactions.
 Learn different molecular techniques to control the mechanism of microbial pathogens.

TEXT BOOKS:
1.Iglewski B.H and Clark V.L ― Molecular basis of Bacterial Pathogenesis ―, Academic Press, 1990.
2.Eduardo A. Groisman, Principles of Bacterial Pathogenesis, Academic Press, 2001.

REFERENCES
1. Peter Williams, Julian Ketley & George Salmond, ―Methods in Microbiology : Bacterial Pathogenesis,
Vol. 27‖, Academic Press, 1998.
2. Recent reviews in Infect. Immun., Mol. Microbiol., Biochem. J., EMBO etc
3. Nester, Anderson, Roberts, Pearsall, Nester, ―Microbiology: A Human Perspective‖, Mc Graw Hill, 3rd
Edition, 2001.

BT17E54 CLINICAL BIOCHEMISTRY L T P C
3 0 0 3
OBJECTIVES:
 To provide information about clinical changes in disorders of metabolic pathways
 To disseminate knowledge about hormone related disorders
 Gain knowledge about lifestyle diseases to protect ourselves
 To interpret laboratory data for proper diagnosis of diseases
 To design methods for the diagnosis and treatment of genetic diseases.

UNIT I DISORDERS OF METABOLIC PATHWAYS 9
Scope of clinical biochemistry.Disorders of carbohydrates, lipids, proteins and nucleic acid metabolisms
(Sickle cell anenmia, Phenyl ketonuria, alkaptonuria, albinism, Nieman Pick disease, Glycogen storage
diseases, Lesch-Nyhan Syndrome and Gout).Diabetes mellitus, clinical features, metabolic
changes.Glycosuria, galactosemia and fructosuria.

UNIT II HORMONAL DISORDERS 9
Classification of hormones-Peptide hormone -vasopressin - protein hormone- insulin -Steroid hormones-
testosterone, estrogen, cortisol – amino acid hormones -thyroxine, adrenaline, noradrenaline.Disorders of
hormones.

UNIT III LIFE STYLE DISEASES 9
Type II Diabetes, Obesity, Artherosclerosis, Heart diseases, High blood pressure, Swimmer‘s ear,Cancer,
Chronic obstructive pulmonary disease, Cirrhosis, Nephritis.

UNIT IV CLINICAL DIAGNOSIS OF DISEASES 9
Composition of blood and urine in normal and disease conditions –their significance-urea, uric acid,
Creatinine, Glucose, bilirubin, total protein, A/G ratio, lipid profile- total cholesterol, HDL, LDL. Organ
function tests (liver, renal and gastric). Diagnostic enzymes and Biomarkers.\

UNIT V BIOTECHNOLOGY AND HUMAN DISEASES 9
Restriction endonucleases- DNA cloning- probes- southern blotting- restriction fragment length
polymorphism- polymerase chain reaction- analysis of gene expression- gene therapy- transgenic animals

TOTAL: 45 PERIODS

Curriculum and Syllabus | B.Tech. Biotechnology | R2017 Page 69