Page 136 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

92 SECTION II BIOCHEmISTRY ``BIOCHEMISTRY—METABOlISM BIOCHEmISTRY ``BIOCHEMISTRY—METABOlISM

Lipid transport
Dietary fat
and
cholesterol
Thoracic duct Chylomicron enters lymphatics
HDL transfers Apo CII and Apo E
Chylomicron Apo CII activates LPL
Liver releases VLDL
Micelles VLDL Apo CII activates LPL
Subclavian vein Adipocyte 6 IDL delivers TGs and cholesterol
to the liver via Apo E
7 Endocytosis of LDL

TG TG
TG
FFA Lipoprotein
Lumen Intestinal cell lipase
Systemic circulation

Apo
B-48
TG TG
Peripheral cell
Hepatocyte
Adipocyte Chylomicron Chylomicron
Chol E
TG Apo CII Cholesterol
HDL TG +
Apo E TGs
TG TG Chylomicron
TG remnant
FFA
LDL receptor Chol E
TG
Apo
B-100 Apo E
7 VLDL receptor Bile
VLDL TG TG canaliculus
LDL Chol E Chol E Chol E
TG IDL
TG
Chol E
6 HDL

Hepatic lipase

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