Page 699 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

RepRoductive ` REPRODUCTIVE—PATHOlOgy RepRoductive ` REPRODUCTIVE—PHARmACOlOgy SectioN iii 655

` REPRODUCTIVE—PHARmACOlOgy

Control of reproductive hormones

Hypothalamus

via blocking negative feedback
Clomiphene + GnRH

Degarelix -
Goserelin –/+
Leuprolide
Anterior
pituitary

LH
FSH

LH LH
FSH
Ovary Testis
Oral contraceptives
Danazol -

Ketoconazole - P-450c17 Ketoconazole
Danazol - Spironolactone

Androstenedione Testosterone Testosterone
Anastrozole
Letrozole - Aromatase 5α−reductase - Finasteride
Exemestane
Estriol Estrone Estradiol Dihydrotestosterone

Tamoxifen –/+
Raloxifene Androgen-receptor Flutamide
complex Cyproterone
Spironolactone
-
Gene expression Gene expression
in estrogen- in androgen-
responsive cells responsive cells

FAS1_2019_15-Repro.indd 655 11/7/19 5:52 PM