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INDEX                                                                                        INDEX                     795




                  Sex hormone–binding globulin   Sign of Leser-Trélat, 228  petechiae, 407        Smoking
                         (SHBG), 337         Sildenafil, 651             pigmentation disorders, 475, 476  abdominal aortic aneurysms and,
                  Sex hormone disorder diagnosis, 639  Silencer (gene expression), 41  plaque, 475      302
                  Sex pilus (bacterial genetics), 130  Silicosis, 677    pustule, 475               atherosclerosis and, 302
                  Sex steroid replacement, 339  Silver stain, 125, 143   scale, 475                 Buerger disease and, 314
                  Sexual abuse, 556, 558     Simeprevir, 204             scaling, 152               bupropion for cessation, 576
                  Sexual behavior            Simple partial seizures, 517  scaly, 66                carcinogenicity of, 225
                    hypothalamus regulation of, 498  Simple pneumothorax, 680  seborrheic keratoses, 228  cataracts, 535
                  Sexual differentiation, 622, 636  Simple renal cysts, 604  splinter hemorrhages, 311  colorectal cancer and, 388
                  Sexual dysfunction         Single nucleotide (point) mutation,   striae, 348      emphysema, 674
                    β-blockers and, 245, 323       39                    T-cell lymphoma, 430       esophageal cancer and, 378
                    cimetidine, 399          Single nucleotide polymorphisms   telangiectasia, 316, 473  head and neck cancer, 671
                    differential diagnosis of, 567  (SNPs), 54           ulcers, 158                hormonal contraception, 657
                    Lambert-Eaton myasthenic   Single nucleotide substitutions, 39  vascular tumors, 478  Legionnaires’ disease, 143
                         syndrome, 472       Single-stranded binding proteins, 38  vasculitides, 314  lung cancer, 684
                    Peyronie disease and, 651  Sinusitis                 verrucous, 151             pancreatic cancer and, 398
                    tuberoinfundibular pathway, 499  brain abscesses, 180  vesicle, 475             renal cell carcinoma, 605
                  Sexually transmitted infections (STIs)  C3 deficiency and, 107  wheal, 475        saccular aneurysms, 516
                    clinical features, 184     Kartagener syndrome, 49  Skip lesions, 382           squamous cell carcinoma of
                    parental consent with, 265  Streptococcus pneumoniae, 136  Skull thickening, 463    bladder, 606
                  Sézary syndrome, 430         Wegener granulomatosis, 315  Slapped cheek rash, 183  stomach cancer and, 379
                  Shawl and face rash, 471   Sinus venosus, 281         Sleep                       teratogenic effects, 614
                  Sheehan syndrome, 339      Sirolimus                   ghrelin/leptin production, 336  transitional cell carcinoma, 606
                  Sheep (disease vectors), 160  immunosuppressant, 120  Sleep disturbance           varenicline for cessation, 576
                  Shiga-like toxin (SLT), 145  Sister Mary Joseph nodules, 379  apnea, 679        Smooth brain, 491
                    cytokine release and, 132  Sitagliptin, 353          benzodiazepines and, 570  Smooth endoplasmic reticulum, 46
                  Shiga toxin, 130, 132, 144  Situs inversus, 49         β-blockers, 245          Smooth muscle
                  Shigella boydii, 144       6-mercaptopurine, 440       delirium and, 558          BMPR2 gene, 679
                  Shigella dysenteriae, 144    azathioprine, 120         generalized anxiety disorder, 563  contraction of, 457
                  Shigella flexneri, 144       for ulcerative colitis, 382  in geriatric patients, 270  glomus tumors, 478
                  Shigella sonnei, 144         purine synthesis, 36      hypnagogic hallucinations, 559  respiratory tree, 662
                  Shigella spp                 targets of, 438           hypnopompic, 559           tumor nomenclature in, 220
                    bloody diarrhea, 179     Sjögren syndrome, 468       paralysis, 568           Smooth muscle (vascular)
                    penicillinase-sensitive penicillins   autoantibody, 115  paroxysmal nocturnal dyspnea,    in arteriolosclerosis, 301
                         for, 188              pilocarpine for, 240           309                   atherosclerosis and, 302
                    reactive arthritis, 469    rheumatoid arthritis, 466  pulsus paradoxus in, 310  calcium channel blocker action,
                    TMP-SMX, 194             Skeletal muscles            sleep terror disorder, 567, 568  318
                    vs Salmonella spp, 144     ACh receptors in, 236     varenicline, 576         Smudge cells, 432
                  Shingles, 165                blood flow regulation in, 297  Sleep physiology, 497  SNARE proteins
                  Shin splints, 461            glycogen metabolism in, 86  stages in, 497           in neurotransmission, 138
                  Shock, 310                   somatic nerve, supply of, 236  Sleepwalking        SNc (substantia nigra pars compacta),
                    dopamine for, 242        Skewed distributions, 262   sleep stages and, 497          495
                    Ebola, 171               Skin                       SLE (systemic lupus erythematosus),   SNRIs (serotonin-norepinephrine
                    endotoxins, 131            blood flow regulation in, 297  470                       reuptake inhibitors )
                    in pulmonary anthrax, 137  collagen in, 50           antiphospholipid syndrome and,   clinical use, 572
                    norepinephrine for, 242    normal flora of, 135           470                   major depressive disorder, 561
                    Waterhouse-Friderichsen syndrome   pigmentation, 56  autoantibodies, 115        mechanism and clinical use, 575
                         and, 349              wrinkles of aging, 52     DPGN, 596                Snuffles, 147
                  short-chain fatty acids    Skin anatomy, 473–483       HLA subtypes, 100        “Soap bubble” appearance/lesions
                    in anaerobic organisms, 127  layers of, 473          kidney disease with, 596   giant cell tumor, 464
                  SIADH, 338                   microscopic terms, 475    Raynaud phenomenon, 472    Cryptococcus neoformans, 153
                    drug raction and, 249      morphology, 475          Sliding hiatal hernia, 370  Social anxiety disorder, 563
                    markers in, 591          Skin cancer, 484           Slime (S) layer, 124        drug therapy for, 572
                    paraneoplastic syndrome, 228  albinism and, 476     Slipped capital femoral epiphysis,    SSRIs for, 575
                  Sialadenitis, 376            Lynch syndrome and, 388        461                   venlafaxine for, 575
                  Sialolithiasis, 376        Skin drug reactions, 250    osteonecrosis, 463       Social engagement
                          x
                  Sialyl Lewis , 215         Skin flora, 178            Slow acetylators, 232       infant deprivation effects, 556
                  Sibling studies, 256       Skin lesions               Small bowel disease, 374  Sodium channel blockers, 322
                  Sickle cell disease, 422, 651  autoimmune disorders, 480  Small cell carcinoma of lung, 684  Sodium channels
                    ESR in, 214                bulla, 475                carcinogens for, 225       cystic fibrosis, 60
                    osteonecrosis and, 463     burns, 483                immunohistochemical stains for,   epilepsy drug effects, 544
                    postsplenectomy state in, 98  café-au-lait spots, 57      227                   local anesthetic effects, 550
                    Streptococcus pneumoniae, 136  cancer, 222           oat cell carcinoma, 684    pacemaker action potential and,
                  Sickle cells, 415            common disorders, 477     paraneoplastic syndromes, 228  292
                  Sideroblastic anemia         crust, 475                Lambert-Eaton myasthenic   permethrin, 200
                    causes and treatment, 419  dermatitis herpetiformis, 381  syndrome, 472       Sodium-glucose co-transporters
                    lead poisoning, 419        erythema multiforme, 151  topotecan for, 442             (SGLT), 334, 353, 373, 584
                    vitamin B  deficiency, 67  Gottron papules, 228     Small interfering RNA (siRNA) 56  Sodium oxybate (GHB)
                          6
                  Sigmoid colon, 383           hyperlipidemia signs, 300, 301  Small intestine, 371  narcolepsy treatment, 568
                  Sigmoid sinus, 503           hyperpigmentation, 395   Small lymphocytic lymphoma (SLL),   Sodium-potassium channels, 236
                  Sigmoid volvulus, 386        inflammatory bowel disease, 382  432               Sodium-potassium pump, 49
                  Signaling pathways           Kaposi sarcoma, 165      Small molecule inhibitors  Sodium stibogluconate, 158, 200
                    endocrine hormones, 337    kwashiorkor, 71           naming conventions for, 254  Sofosbuvir, 204
                    steroid hormones, 337      macule, 475              Smallpox, 164             Solifenacin, 241
                  Signal recognition particle (SRP), 47  papule, 475    Small-vessel vasculitis   Solitary functioning kidney, 579
                  Signet ring cells, 379       patch, 475                presentation and pathology, 314  Solitary nucleus of medulla, 296







          FAS1_2019_21_Index_749-806.indd   795                                                                        11/21/19   12:27 PM
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