Page 140 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. CO 2 dissociation curve
CO 2 concentration O 2 saturation = 0.00
of blood (mmol/L)
30 -
Normal range: a–v
v -
25 Total CO 2 in blood
mixed venous (=100%)
arterial O 2 saturation = 1.00 –
20 Plasma-HCO 3 CO 2
a CO 2 Binding in Blood, CO 2 in CSF
15 mixed venous Bound CO 2 60%
arterial 29%
10

Dissolved CO 2
5 Carbamate
–
RBC-HCO 3
0
0 2 4 6 8 10 Plate 5.11
kPa P CO 2
0 10 20 30 40 50 60 70 80
mmHg
B. Effect of CO 2 on pH of CSF
Example: 1 Acute
Respiratory acidosis 2 Chronic
Renal
compensation
–
CO 2 HCO 3 –
CO 2 HCO 3
H 2 O
+
H
Rapid diffusion Blood-CSF pH NBB Blood H 2 O pH H + NBB Slow diffusion
barrier

–
CO 2 HCO 3
–
CO 2 HCO 3
H 2 O H + CSF
H 2 O H +
pH NBB
pH ( )
Central
chemoreceptors Central
chemoreceptors
Strong signal for 127
respiratory regulation Weak signal
(adaptation)
Despopoulos, Color Atlas of Physiology © 2003 Thieme
All rights reserved. Usage subject to terms and conditions of license.