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A.  Olfactory pathway and olfactory sensor specificity
          1  Nasal cavity
                                          2  Olfactory pathway
                             Olfactory bulb
                                           Olfactory bulb
                             Fila olfactoria
                             Olfactory region
                                   Granular cell
                                    Mitral cell
                                    Reciprocal
         Air                      synapses (+/–)
                                    Bristle cells                      Sense of Smell
                                  Periglomerular
                                        cell
        3  Sensor specificity (example)
                              AP/Stimulus
            ortho  meta    para
            CH 3  CH 3                                                 Plate 12.16
                                  Glomerulus 1
             CH 3   CH 3  CH 3  CH 3
                                  Glomerulus 2
         Length of side chain  CH 3 CH 2 CH 3  CH 3  CH 2 CH 3  CH 3  CH 2 CH 3  olfactoria
                                       Fila

                                    Olfactory
                 CH 3
            CH 3
                                   sensor cells
             CH 2 CH 2 CH 3  CH 2 CH 2 CH 3  CH 3  CH 2 CH 2 CH 3
                                       Cilia
                       (After K. Katoh et al.)  Mucus   (After K. Mori et al.)
         B.  Transduction of olfactory stimuli  C.  Adaptation of smell and taste
         Mucous layer  Odorant  Cation    Gustatory stimulus: 2mol/L NaCl
                                          Olfactory stimulus: 0.02mol/LH 2 S
                      channel
                  Receptor            100   Smell
         Cell membrane  GTP  G s  -protein  Intensity of perception (%)  50



         GDP                              Taste
                   Adenylate
                    cyclase
         ICF
            ATP               Na +      0    1    2    3    4    5
                     cAMP     Ca 2+                    Time (min)     341
                                                    (After Engel and Ekman et al.)
       Despopoulos, Color Atlas of Physiology © 2003 Thieme
       All rights reserved. Usage subject to terms and conditions of license.
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