Page 351 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
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A.  Disorders of Sleep Regulation  B.  Sleep Phases
                Cortex
                          Somnambulism                       Normal
        Lesions,                        Awake
        ischemia                        I
                         Asynchronous  II
                  Thalamus  Somnolence  Stages of sleep  III  REM
             SCN  Hypo-                IV
                thalamus     ARAS

                         NR
                    Reticular                   Excessive use of sleeping pills
                    formation  LC      Awake                           Sleep Disorders
        Insomnia, hypersomnia          I
          Metabolic        Respiratory  II
          alkalosis         center     III
         Abnormal
         regulation  Muscle tone       IV
                   Stridor                                             Plate 10.22
                           Sleep apnea     1  2  3  4  5  6  7  8
                              Hypoxia               Hours
        C.  Sleep Factors
                                                 Normal sleep phases
              1   Day  Night    NREM sleep pressure
            Sleep pressure  1/REM sleep pressure  Net sleep pressure  Depth of sleep






                      ‘Normal’ on-                  Tage
                       set of night
                               Jet lag      Delayed sleep phase insomnia
              2    East West           3
                                               Diurnal rhythm
                                                displaced




                            Depression                 Excitement
              4                        5
                            Sleep               Raised level
             Serotonin deficiency (?)  deprivation  of excitement


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       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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