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206  P R I N C I P L E S   A N D   P R A C T I C E   O F   C R I T I C A L   C A R E

         ventricular ejection time difficult), or pulmonary oedema,   with a small amount of air, injected into the peripheral
         pleural  effusions  or  chest  wall  oedema  (which  alter    vein to produce images of the heart functions. 66
         bioimpedance  readings  irrespective  of  any  changes  in   In the critical care setting, the preparation of critically ill
         cardiac output). The use of transthoracic bioimpedance   patients  for  this  examination  is  important.  The  nurse
         in critically ill patients is variable, due in part to limita-  needs to help the sonographer to position the patient to
         tions of its usefulness in patients who have pulmonary   achieve  best  results.  For  TOE  preparation,  fasting  time
         oedema. 87,88
                                                              must be followed to avoid complications such as respira-
                                                              tory  aspiration.  The  nurse  will  also  need  to  assist  the
                                                              anaesthetist  and  the  TOE  operator,  and  continue  to
                                                              monitor  the  patient’s  clinical  conditions  during  the
            Practice tip                                      procedure.
            Current  evidence-based  literature  suggests  that  haemody-  BLOOD TESTS
            namic measurements such as CVP, PAWP and PAP can be accu-
            rately measured with the patient’s position of supine to head   A number of blood tests are often conducted to assist the
            – up to 60 degrees. 28                            clinical assessment of the critically ill patients in the criti-
                                                              cal care setting.

                                                              Full Blood Count
         DIAGNOSTICS                                          The full blood count (FBC) assesses the status of three
                                                              major  cells  that  are  formed  in  the  bone  marrow:  red
         Apart from the haemodynamic monitoring methods to    blood cells (RBC), white blood cells (WBC) and platelets.
         facilitate  cardiac  assessment  of  patients’  clinical  condi-  Although normal values have been given (see Appendix
         tion, a variety of diagnostic tests are often used. Echocar-  C), for critically ill patients changes will occur in certain
         diography and blood tests are the most commonly used   conditions. For example, Hb is reduced in the presence
         in critical care. Other tests such as Computerised Tomo-  of haemorrhage and also in acute fluid overload causing
         graphy (CT) and Nuclear medicine cardiac examination   haemodilution.
         are  also  used  when  indicated.  Exercise  stress  tests  and
         cardiac  angiography  are  also  used  and  are  reviewed  in   Haemoconcentration  can  occur  during  acute  dehydra-
         Chapter 10.                                          tion, which would show as a high Hb. Similar conditions
                                                              will also affect the haematocrit. WBC levels will be ele-
         ECHOCARDIOGRAPHY                                     vated  during  episodes  of  infection,  tissue  damage  and
                                                              inflammation. When infections are severe, the full blood
         Echocardiography (shortened to ECHO) is often used in   count will show a dramatic rise in the number of imma-
         critical care to assess patients’ cardiovascular conditions   ture neutrophils. Platelets are easily lost during haemor-
         such  as  heart  failure,  hypertensive  heart  disease,  valve   rhage, and spontaneous bleeding is a danger when the
         disease, and pericardial disease in critically ill patients. It   count falls to below 20 × 10 /L. 91,92
                                                                                       9
         adopts a technique of detecting the echoes produced by
         a heart from a beam of very high frequency sound – the   Electrolytes
         ultrasound.  Two  dimensional,  three  dimensional  and
         contrast  ECHO  images  can  be  obtained  using  non-  The assessment of electrolyte levels in critically ill patients
         invasive  transthoracic  technique  or  the  invasive  trans-  is important in diagnosing the patient’s condition. Elec-
         oesophageal technique (TOE). The transthoracic ECHO   trolyte imbalances, such as potassium and calcium level
         uses a transducer probe externally to the heart to obtain   changes, can cause cardiovascular abnormalities such as
         images  (same  as  a  normal  ultrasound  technique).  This   arrhythmias. Electrolyte levels are often checked regularly
         method  is  painless  and  does  not  require  sedation.  The   in critically ill patients.
         TOE technique involves placing a transducer probe into   The  functions  of  electrolytes  and  their  cardiac  implica-
         the oesophageal cavity to assess the function and struc-  tions are listed in Table 9.5.
         ture of the heart. This method produces better images of
                                      66
         the heart than the normal ECHO.  However this method   Cardiac Enzymes
         requires sedation during the procedure and the patient
         needs to fast for a few hours prior to the examination.  Recent studies have revealed that cardiac troponin levels
                                                              are  elevated  in  critically  ill  septic  patients  who  do  not
         Two-dimensional  ECHO  images  are  valuable  resources   have evidence of MI. Further, mortality rates are higher
         for assessment of the function and structure of the heart.   in  troponin-positive  patients  than  in  those  who  are
         Three dimensional images offer more realistic visualisa-  troponin-negative,  suggesting  that  this  may  become  an
         tion  of  the  heart’s  structure  and  function.  The  contrast   important enzyme to measure; however, more research is
         ECHO provides enhanced images of left and right ven-  still  required  to  refine  the  testing. 93,94   For  patients  with
         tricular definition to facilitate the diagnosis of complex   suspected  acute  myocardial  infarction,  testing  of  the
         cardiac conditions such as congenital heart defects, valve   enzyme troponin T or I is now standard. But not all criti-
         stenosis and regurgitation. 83,89,90  The contrast ECHO tech-  cally  ill  patients  with  elevated  cardiac  troponin  levels
         nique  uses  gas  air  microbubbles,  produced  by  hand-  should be treated as having myocardial infarction unless
                                                                                          95
         agitating  a  syringe  containing  10 mL  of  normal  saline   there is support from other data.  All injured cells release
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