Page 2643 - Hematology_ Basic Principles and Practice ( PDFDrive )

e24 Part XIII Consultative Hematology

TABLE Complement Fractions C3 and C4 in Males and TABLE Platelet Counts and Mean Platelet Volumes in
162.27 Females, by Age 162.28 Children and Adults
9
Study Age g/L Age (Years) Platelet Count (10 /L) Mean Platelet Volume (fL)
C3 1–10 220–422 8.3–10.9
Zillow et al (1993) a Healthy neonates 0.30–0.98 10–18 165–396 8.6–12.1
Lockitch et al (1988) b 0–5 days 0.26–1.04 18–45 159–376 8.5–12.8
1–19 years 0.51–0.95 45–65 (males) 156–300 8.6–12.0
Adult 0.45–1.8
C4 45–65 (females) 156–351 9.0–12.9
Lockitch et al (1988) b 0–5 days 0.06–0.37 >65 139–363 8.8–12.4
1–19 years 0.08–0.44 Data from Giacomini A, Legovini P, Gessoni G, et al: Platelet count and
Adult 0.11–0.5 parameters determined by the Bayer ADVIA 120 in reference subjects and
patients. Clin Lab Haematol 23:181, 2001. Fifty male and 50 female subjects
a From Zillow G, Zillow EP, Burger R, et al: Complement activation in newborn per age range were tested. Range represents 95% confidence limits.
infants with early onset infection. Pediatr Res 34:199, 1993. Results are
0–100th percentiles. Thirty-two healthy full-term newborns, birth weights
between 2500 and 4020 g, were tested. All mothers (vagina, rectum) and
infants (ear, gastric) were culture negative.
b Lockitch G, Halstead AC, Quigley G, et al: Age- and sex-specific pediatric
reference intervals: Study design and methods by measurement of serum TABLE Immature Platelet Fraction Reference Values in
proteins with the Behring LN nephelometer. Clin Chem 34:1618, 1988. Results 162.29 Healthy Adults
are 0.025th to 0.975th fractiles.
N Mean (%) Range (%)
50 3.4 1.1–6.1 a
142 1.7 0.4–5.4 b
129 3.3 1.0–10.3 c
a Briggs C, Kunka S, Hart D, et al: Assessment of an immature platelet fraction
(IPF) in peripheral thrombocytopenia. Br J Haematol 126:93, 2004.
b Cho YG, Lee JH, Kim DS, et al: Clinical usefulness of the simple technique to
diagnose thrombocytopenia using immature platelet fraction. Korean J Lab Med
27(1):1, 2007.
c Abe Y, Wada H, Tomatsu H, et al: A simple technique to determine
thrombopoiesis level using immature platelet fraction (IPF). Thromb Res
118:463, 2006.

TABLE
162.30 Reference Values for Coagulation Tests in Infants, Children, and Adults
Coagulation Test Day 1 Day 3 1 month–1 year 1–5 years 6–10 years 11–16 Years Adults
PT (s) 15.6 a 14.9 a 13.1 13.3 a 13.4 a 13.8 a 13
14.4–16.4 13.5–16.4 11.5–15.3 12.1–14.5 11.7–15.1 12.7–16.1 11.5–14.5
INR 1.26 a 1.20 a 1 1.03 a 1.04 a 1.08 a 1
1.15–1.35 1.05–1.35 0.86–1.22 0.92–1.14 0.87–1.20 0.97–1.30 0.80–1.20
aPTT (s) 38.7 a 36.3 a 39.3 a 37.7 a 37.3 a 39.5 a 33.2
34.3–44.8 29.5–42.2 35.1–46.3 33.6–43.8 31.8–43.7 33.9–46.1 28.6–38.2
Fibrinogen (g/L) 2.8 3.3 2.42 a 2.82 a 3.04 3.15 3.1
1.92–3.74 2.83–4.01 0.82–3.83 1.62–4.01 1.99–4.09 2.12–4.33 1.9–4.3
II 54 a 62 a 90 a 89 a 89 a 90 a 110
41–69 50–73 62–103 70–109 67–110 61–107 78–138
V 81 a 122 113 97 a 99 a 89 a 118
64–103 92–154 94–141 67–127 56–141 67–141 78–152
VII 70 a 86 a 128 111 a 113 a 118 129
52–88 67–107 83–160 72–150 70–156 69–200 61–199
VIII 182 159 94 a 110 a 117 a 120 a 160
105–329 83–274 54–145 36–185 52–182 59–200 52–290
vWF b N/A N/A N/A 82 95 100 92
60–120 44–144 46–153 50–158
IX 48 a 72 a 71 a 85 a 96 a 111 a 130
35–56 44–97 43–121 44–127 48–145 64–216 59–254
X 55 a 60 a 95 a 98 a 97 a 91 a 124
46–67 46–75 77–122 72–125 68–125 53–122 96–171
XI 30 a 57 a 89 a 113 113 11 112
7–41 24–79 62–125 65–162 65–162 65–139 67–196