Page 2641 - Hematology_ Basic Principles and Practice ( PDFDrive )

e22 Part XIII Consultative Hematology

TABLE
162.23 Plasma Levels of Immunoglobulin G in Males and Females, by Age
Male Female
Age Number mg/dL g/L Number mg/dL g/L
Soldin et al (1996) a
1–30 days 61 260–986 2.60–9.86 56 221–1031 2.21–10.31
31–182 days 52 195–643 1.95–6.43 60 390–794 3.90–7.94
183–365 days 37 184–974 1.84–9.74 23 407–774 4.07–7.74
1–3 years 105 507–1305 5.07–13.05 127 550–1407 5.50–14.07
4–6 years 138 571–1550 5.71–15.50 135 675–1540 6.75–15.40
7–9 years 111 700–1680 7.00–16.80 105 589–1717 5.89–17.17
10–12 years 104 818–1885 8.18–18.85 115 705–1871 7.05–18.71
13–15 years 104 709–1861 7.09–18.61 118 891–1907 8.91–19.07
16–18 years 112 632–1979 6.32–19.79 100 953–2108 9.53–21.08
Male/Female
Age mg/dL g/L
Lockitch et al (1988) b
0–12 months 273–1660 2.73–16.60
1–3 years 533–1078 5.33–10.78
4–6 years 593–1723 5.93–17.23
7–9 years 673–1734 6.73–17.34
10–11 years 821–1835 8.21–18.35
12–13 years 893–1823 8.93–18.23
14–15 years 842–2013 8.42–20.13
16–19 years 646–1864 6.46–18.64
a Soldin SJ, Bailey J, Beatey J, et al: Pediatric reference ranges for immunoglobulins G, A, and M on the Behring nephelometer. Clin Chem 42:S308, 1996.
b Lockitch G, Halstead AC, Quigley G, et al: Age- and sex-specific pediatric reference intervals: Study design and methods illustrated by measurement of serum proteins
with the Behring LN nephelometer. Clin Chem 34:1618, 1988. Results are 0.025th to 0.975th fractiles.

TABLE a
162.24 Immunoglobulin G Subclasses
Age IgG1 IgG2 IgG3 IgG4
Cord blood, preterm 3.4–9.7 0.7–1.7 0.2–0.5 0.2–0.7
Cord blood, term 5.8–13.7 0.6–5.2 0.2–1.2 0.2–1.0
5 years 5.6–12.7 0.4–4.4 0.3–1.0 0.1–0.8
6 years 6.2–11.3 0.5–4.0 0.3–0.8 0.2–0.9
7 years 5.4–10.5 0.9–3.5 0.3–1.1 0.2–1.1
8 years 5.6–10.5 0.7–4.5 0.2–1.1 0.1–0.8
9 years 3.9–11.4 0.7–4.7 0.4–1.2 0.2–1.0
10 years 4.4–10.8 0.6–4.0 0.3–1.2 0.1–0.9
11 years 6.4–10.9 0.9–4.3 0.3–0.9 0.2–1.0
12 years 6.0–11.5 0.9–4.8 0.4–1.0 0.2–0.9
13 years 6.1–11.5 0.9–7.9 0.2–1.1 0.1–0.8
Adults 4.8–9.5 1.1–6.9 0.3–0.8 0.2–1.1
a Values for males and females, expressed in g/L. Twenty schoolchildren from
each age-group were tested. Only samples with C-reactive protein within the
reference range were included. Enzyme-linked immunosorbent assay
methodology was used on serum.
From Miles J, Riches P: The determination of IgG subclass concentrations in
serum by enzyme-linked immunosorbent assay: Establishment of age-related
reference ranges for cord blood samples, children aged 5–13 years and adults.
Ann Clin Biochem 31:245, 1994.