Page 107 - Clinical Immunology_ Principles and Practice ( PDFDrive )
P. 107
92 PARt oNE Principles of Immune Response
FUTURE LEARNING AND RESOURCES 14. Trowsdale J, Parham P. Mini-review: defense strategies and
immunity-related genes. Eur J Immunol 2004;34(1):7–17.
This chapter provides only a limited sketch of this fascinating, 15. Lilley BN, Ploegh HL. Viral modulation of antigen presentation:
but complex, topic. The reader is referred to the HLA Facts Book manipulation of cellular targets in the ER and beyond. Immunol Rev
2005;207:126–44.
for a more detailed and very accessible presentation, although 16. Raulet DH. Missing self recognition and self tolerance of natural killer
slightly out of date. There are also a number of websites with (NK) cells. Semin Immunol 2006;18(3):145–50.
extremely useful information. Four stand out in terms of their 17. Murphy K, et al. Janeway’s immunobiology. 8 ed. New York: Garland
utility and the curated quality of the information. (i) The IMGT/ Science; 2012.
HLA Database contains all MHC sequences and has a variety 18. Winchester R. The genetics of autoimmune-mediated rheumatic diseases:
of sequence alignments of different alleles as well as specialized clinical and biologic implications. Rheum Dis Clin North Am
sequence searches (http://www.ebi.ac.uk/imgt/hla/index.html 2004;30(1):213–27, viii.
and http://hla.alleles.org). (ii) The NCBI maintains dbMHC, 19. Vinay DS, et al. Immune evasion in cancer: Mechanistic basis and
which includes several components of the international histo- therapeutic strategies. Semin Cancer Biol 2015;35(Suppl.):S185–98.
compatibility working group (IHWG) that are of interest. Among 20. Rouas-Freiss N, et al. The dual role of HLA-G in cancer. J Immunol Res
2014;2014:359748.
these is the anthropology database, which contains HLA class I 21. Wurz GT, Kao CJ, DeGregorio MW. Novel cancer antigens for
and class II allele and haplotype frequencies in various human personalized immunotherapies: latest evidence and clinical potential.
populations (http://www.ncbi.nlm.nih.gov/projects/mhc/). (iii) Ther Adv Med Oncol 2016;8(1):4–31.
Information about the genes and the genetic organization of 22. Holoshitz J. The quest for better understanding of HLA-disease
the MHC is contained in several sites, but perhaps the most association: scenes from a road less travelled by. Discov Med
comprehensive and comprehensible is that using the Entrez search 2013;16(87):93–101.
engine (http://www.ncbi.nlm.nih.gov). (iv) A comprehensive 23. Farh KK, et al. Genetic and epigenetic fine mapping of causal
database of MHC ligands and peptide motifs is located at http:// autoimmune disease variants. Nature 2015;518(7539):337–43.
www.syfpeithi.de. 24. Ladewig E, et al. Discovery of hundreds of mirtrons in mouse and human
small RNA data. Genome Res 2012;22(9):1634–45.
25. Mehra NK, et al. The HLA complex in biology and medicine : a resource
Please check your eBook at https://expertconsult.inkling.com/ book. New Delhi: Jaypee Bros. Medical Publishers; 2010.
for self-assessment questions. See inside cover for registration 26. Warrens A, Lechler R. HLA in health and disease. San Diego, Calif.;
details. London: Academic; 2000.
27. Tiwari JL, Hla and disease associations. 2012, [Place of publication not
REFERENCES identified]: Springer.
28. Schlosstein L, et al. High association of an HL-A antigen, W27, with
1. Shiina T, et al. The HLA genomic loci map: expression, interaction, ankylosing spondylitis. N Engl J Med 1973;288(14):704–6.
diversity and disease. J Hum Genet 2009;54(1):15–39. 29. Mignot E. Genetics of narcolepsy and other sleep disorders. Am J Hum
2. Aken BL, et al. The Ensembl gene annotation system. Database (Oxford) Genet 1997;60(6):1289–302.
2016;2016. 30. Bradfield JP, et al. A genome-wide meta-analysis of six type 1 diabetes
3. Clark PM, Kunkel M, Monos DS. The dichotomy between disease cohorts identifies multiple associated loci. PLoS Genet
phenotype databases and the implications for understanding complex 2011;7(9):e1002293.
diseases involving the major histocompatibility complex. Int J 31. Winchester R. The molecular basis of susceptibility to rheumatoid
Immunogenet 2015;42(6):413–22. arthritis. Adv Immunol 1994;56:389–466.
4. Dapprich J, et al. The next generation of target capture technologies 32. Goronzy JJ, Weyand CM. Rheumatoid arthritis. Immunol Rev
- large DNA fragment enrichment and sequencing determines regional 2005;204:55–73.
genomic variation of high complexity. BMC Genomics 2016;17(1):486. 33. Michou L, et al. Validation of the reshaped shared epitope HLA-
5. Lund O, et al. Definition of supertypes for HLA molecules using DRB1 classification in rheumatoid arthritis. Arthritis Res Ther
clustering of specificity matrices. Immunogenetics 2004;55(12):797–810. 2006;8(3):R79.
6. Kelley J, Walter L, Trowsdale J. Comparative genomics of natural killer 34. Hussman JP, et al. GWAS analysis implicates NF-kappaB-mediated
cell receptor gene clusters. PLoS Genet 2005;1(2):129–39. induction of inflammatory T cells in multiple sclerosis. Genes Immun
7. Parham P. Immunogenetics of killer cell immunoglobulin-like receptors. 2016;17(5):305–12.
Mol Immunol 2005;42(4):459–62. 35. Greco L, et al. The first large population based twin study of coeliac
8. Beck S, Trowsdale J. The human major histocompatability complex: disease. Gut 2002;50(5):624–8.
lessons from the DNA sequence. Annu Rev Genomics Hum Genet 36. Cheng CY, et al. HLA associations and clinical implications in T-cell
2000;1:117–37. mediated drug hypersensitivity reactions: an updated review. J Immunol
9. Lanier LL. On guard–activating NK cell receptors. Nat Immunol Res 2014;2014:565320.
2001;2(1):23–7. 37. Lind C, Ferriola D, Mackiewicz K, et al. Next-generation sequencing: the
10. Pablo Gomez-Prieto CP-L, Diego Rey Enrique Moreno, Antonio solution for high-resolution unambiguous human leukocyte antigen
Arnaiz-Villena HLA-G, -F and -E. Mehra NK, editor. Polymorphism, typing. Hum Immunol 2010;71:1033–42.
Function and Evolution in The HLA Complex in Biology and Medicine A 38. Duke JL, et al. Determining performance characteristics of an NGS-based
Resource Book. Jaypee Brothers Medical Publishers Ltd; 2010. p. 159–74. HLA typing method for clinical applications. HLA 2016;87(3):141–52.
11. Karlsson L. DM and DO shape the repertoire of peptide-MHC-class-II 39. Nunes E, et al. Definitions of histocompatibility typing terms:
complexes. Curr Opin Immunol 2005;17(1):65–70. Harmonization of Histocompatibility Typing Terms Working Group.
12. Housset D, Malissen B. What do TCR-pMHC crystal structures teach us Hum Immunol 2011;72(12):1214–16.
about MHC restriction and alloreactivity? Trends Immunol 40. Detrick B, Schmitz JL, Hamilton RG, Manual of molecular and clinical
2003;24(8):429–37. laboratory immunology. [Chapter 113. Molecular Methods for Human
13. Stefanova I, et al. On the role of self-recognition in T cell responses to Leukocyte Antigen Typing: Current Practices and Future Directions. ASM
foreign antigen. Immunol Rev 2003;191:97–106. Press June 10, 2016; p 1069–1090] 2016.

