Page 1351 - Clinical Immunology_ Principles and Practice ( PDFDrive )

APPENDIX 1

Selected CD Molecules and

Their Characteristics

Thomas A. Fleisher

CD Molecule Predominant Distribution Identity/Function
CD1a–e Thymocytes, subset of lymphocytes, MHC class I–like molecules; presentation of nonpeptide antigens to T cells; thymic T-cell
antigen-presenting cells development
CD2 T cells Binds to LFA-3; receptor for CD48; T-cell activation; adhesion
CD3 T cells T-cell signaling complex; associated with TCR
CD4 T-cell subset TCR coreceptor; interacts with MHC class II molecules on antigen-presenting cells; identifies
T cells with helper function; signal transduction
CD5 Most T cells, thymocytes, B-cell subset Binds to CD72; regulation of cell proliferation/activation; identifies B-1 B-cell subset
CD6 Thymocytes, T cells, B-cell subset Binds CD166 (ALCAM); adhesion; mediates binding of developing thymocytes with thymic
epithelial cells; thymic development; T-cell activation
CD7 Pluripotent hematopoietic cells, T-cell and NK-cell development
thymocytes, T cells
CD8 T-cell subset TCR coreceptor; interacts with MHC class I molecules on antigen-presenting cells; identifies
T cells with cytotoxic function
CD10 B cells Neutral endopeptidase; enkephalinase; B-cell development; common acute lymphoblastic
leukemia antigen (CALLA), neutrophils
CD11a Leukocytes α-chain of LFA-1; pairs with CD18; interacts with ICAM; adhesion and cellular migration
CD11b Monocytes, granulocytes, NK cells α-chain of complement receptor type 3 (CR3); pairs with CD18; adhesion molecule
CD11c Monocytes, granulocytes, NK cells α-chain of complement receptor type 4 (CR4); pairs with CD18; adhesion molecule
CD13 Hematopoietic stem cells, immature Appears before CD33 during myeloid differentiation
and mature myeloid and monocyte
elements
CD14 Granulocytes, monocytes/macrophages Receptor for LPS/LPB complex; myeloid differentiation antigen; cell activation
CD15 Neutrophils, eosinophils, monocytes, Sialyl Lewis X antigen, plays a role in cell adhesion, defective in leukocyte adhesion
basophil subset deficiency type 2
CD16a,b NK cells, monocytes/macrophages, FcγRIIIA and FcγRIIIB (low-affinity IgG receptors-type III); phagocytosis; ADCC
neutrophils
CD18 Leukocytes β-chain of β 2 -integrin molecules, including LFA-1, CR3, and CR4; pairs with CD11a, b, and c
CD19 B cells BCR coreceptor; signal transduction; complexes with CD21, expressed pre-B cells
CD20 B cells Role in B-cell activation/differentiation
CD21 B cells; follicular dendritic cells Complement receptor type 2 (CR2): C3d receptor; B-cell coreceptor subunit; EBV receptor
CD22 B cells Associates with BCR; signaling; regulation of B-cell activation; adhesion
CD23 B cells, macrophages, eosinophils, FcεRII; (low-affinity IgE receptor), activated B cells
platelets, follicular dendritic cells
CD24 Leukocytes Heat-stable antigen; costimulation; adhesion
CD25 Activated T cells and B cells α-chain of IL-2 receptor, low-affinity IL-2 binding; signaling for cell proliferation/differentiation
CD26 Activated T cells and B cells; Dipeptidyl peptidase; role in extracellular adhesion; cell activation
macrophages
CD27 T cells; B-cell subset Costimulation; T-cell proliferation, memory B cells
CD28 T cells Binds B7-1 (CD80) and B7-2 (CD86); T-cell costimulation; signal transduction
CD29 Leukocytes Integrin β 1 -chain; pairs with CD49a-CD49f to form VLA-1-VLA-6 integrins, respectively;
adhesion; signal transduction; development
CD30 Activated B cells and T cells Binds to CD153; T-cell activation/regulation/differentiation, Reed–Sternberg cells
CD31 Monocytes, granulocytes, platelets, PECAM-1; binds to CD38; adhesion; signal transduction
endothelial cells, B cells
Recent thymic emigrants
CD32 B cells, monocytes/macrophages, FcgRII (low-affinity IgG receptor-type II) phagocytosis; ADCC; B-cell regulation
granulocytes, eosinophils
CD33 Myeloid progenitors, granulocytes Binds sialic acid
CD34 Hematopoietic progenitor cells; capillary Mucosialin; binds to CD62L; adhesion
endothelium

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