Page 1353 - Clinical Immunology_ Principles and Practice ( PDFDrive )

APPENDIX 1 Selected CD Molecules and Their Characteristics 1313

CD Molecule Predominant Distribution Identity/Function
CD73 B-cell and T-cell subsets Ecto-5′ nucleotidase; allows nucleoside uptake
CD74 MHC class II expressing cells MHC class II–associated invariant chain; involved in antigen processing and peptide
presentation in antigen-presenting cells
CD77 Germinal center B cells Entering apoptosis
CD79a,b B cells Iga, Igb; components of BCR complex that mediate signal transduction
CD80 Monocytes/macrophages, dendritic B7-1; ligand for CD28 and CTLA-4; T-cell interaction with antigen-presenting cells;
cells, activated B cells costimulation
CD81 Lymphocytes Associates with CD19 and CD21 to form B-cell coreceptor complex; costimulation; adhesion
CD86 Monocytes, activated B cells B7-2; ligand for CD28 and CTLA-4; T-cell interaction with antigen-presenting cells;
costimulation
CD87 Granulocytes; monocytes/ Urokinase plasminogen activator receptor
macrophages, activated T cells
CD88 Granulocytes, macrophages, mast cells Complement component fragment C5a receptor
CD89 Monocytes/macrophages, granulocytes, FcαR (IgA receptor)
B-cell and T-cell subsets
CD91 Monocytes α 2 -macroglobulin receptor
CD94 NK cells, T-cell subset Inhibits killing
CD95 Broad distribution Fas or APO-1; induces apoptosis after being bound by Fas ligand
CD97 Activated B and T cells, monocytes, Activation antigen
PMN
CD102 Resting lymphocytes, monocytes, ICAM-2; binds LFA-1 (CD11a/CD18); adhesion; T-cell costimulation
endothelial cells
CD103 Intraepithelial lymphocytes, T-cell αE integrin; T-cell development and costimulation
subset
CD104 Epithelial cells, Schwann cells β 4 -integrin; epidermal adhesion to basement membrane
CD105 Endothelial cells, bone marrow cell Endoglin; adhesion
subset, activated macrophages
CD106 Endothelial cells VCAM-1; ligand for VLA-4; lymphocyte adhesion; embryonic development
CD107a,b Epithelial cells, subsets of monocytes, LAMP-1 and LAMP-2; adhesion
granulocytes, and lymphocytes
CD110 Hematopoietic stem cells, Thrombopoietin receptor; megakaryocyte proliferation and differentiation
megakaryocytes, platelets
CD114 Granulocytes G-CSF receptor; regulates granulopoiesis
CD115 Monocytes/macrophages M-CSF receptor; cell differentiation
CD116 Monocytes, neutrophils, eosinophils GM-CSF a chain receptor; cell differentiation
CD117 Hematopoietic progenitors, mast cells c-kit; stem cell factor (SCF) receptor; hematopoietic cell differentiation
CD118 Broad distribution Type 1 interferon (interferon-α/β) receptor
CD119 Broad distribution Interferon-γ receptor
CD120a Hematopoietic cells, nonhematopoietic TNF receptor-type I signal transduction; apoptosis
cells, myeloid cells
CD120b Hematopoietic cells, nonhematopoietic TNF receptor-type II; signal transduction; apoptosis
cells, myeloid cells
CD121a Thymocytes, T-cell subset, fibroblasts, IL-1 receptor-type I; signal transduction
epithelial cells, and brain cells
CD121b T-cell subset, myeloid cell subsets IL-1 receptor-type II
CD122 NK cells, T-cell and B-cell subset IL-2 and IL-15 receptor β chain; signal transduction; regulation of lymphocyte development,
differentiation, activation, and proliferation
CD123 Bone marrow stem cells, granulocytes, IL-3 receptor α chain; cell development and differentiation
monocytes, megakaryocytes
CD124 Mature B cells and T cells, IL-4 receptor; signal transduction; lymphocyte development, activation, differentiation, and
hematopoietic precursor cells proliferation
CD125 Eosinophils, basophils, B-cell subset IL-5 receptor; eosinophil and B-cell growth and differentiation
CD126 Activated B cells, plasma cells, T cells, IL-6 receptor α chain; regulation of B-cell and T-cell differentiation and function;
granulocytes, monocytes/ hematopoiesis
macrophages; also expressed on
epithelial cells, fibroblasts,
hepatocytes, and neural cells
CD127 Bone marrow lymphoid precursors, IL-7 receptor α chain; signal transduction; B-cell and T-cell proliferation and differentiation
pro-B cells, T-cell precursors, T-cell
subset, monocytes
CD128 Neutrophils, basophils, T-cell subset IL-8 receptor; neutrophil activation and migration
CD129 T cells IL-9 receptor α chain; T-cell proliferation
CD130 Broad distribution IL-6 receptor β chain (with CD126); signal transduction
CD131 Lymphocytes, granulocytes, monocytes IL-3, IL-5, and GM-CSF receptor; common β chain; signal transduction; see CD123 and
CD125
CD132 Lymphocytes Common γ chain of high-affinity receptor for IL-2 (with CD25 and CD122), IL-4 (with CD124),
IL-7 (with CD127), IL-9 (with CD129), and IL-15 (with CD122) receptors; signal transduction
Continued