Page 1352 - Clinical Immunology_ Principles and Practice ( PDFDrive )

1312 APPENDIX 1 Selected CD Molecules and Their Characteristics

CD Molecule Predominant Distribution Identity/Function
CD35 Leukocytes; erythrocytes Complement receptor 1 (CR1); C3b and C4b receptor; phagocytosis
CD36 Monocytes/macrophages; endothelium; Binds oxidized LDL; scavenger receptor; binds apoptotic cells; adhesion and endocytic
platelets receptor; GPIIIb; platelet adhesion and aggregation
CD38 NK cells; T-cell and B-cell subsets; Binds CD31; cyclase; hydrolase; cell activation
monocytes
CD40 B cells; antigen-presenting cells Binds CD154 (CD40 ligand); B-cell proliferation, differentiation, and survival; T-cell
costimulation
CD41 Megakaryocytes/platelets Glycoprotein IIb; a IIb integrin chain; binds fibronectin, fibrinogen, von Willebrand factor,
thrombospondin; extracellular adhesion; platelet aggregation
CD43 Leukocytes (except resting B cells) Leukocyte sialoglycoprotein; may bind CD54; signal transduction; adhesion; antiadhesion
CD44 Leukocytes; memory T cells; Binds hyaluronan (H-CAM), collagen, fibronectin, laminin, osteopontin; extra- and intercellular
erythrocytes adhesion; T-cell costimulation; leukocyte homing
CD45 Leukocytes (pan-leukocyte marker) Protein tyrosine phosphatase; cell differentiation; lymphocyte signal transduction and
activation
CD45RA Naive T-cell marker (in conjunction with CD45 isoform
CD62L); B cells, monocytes
CD45RB B-cell and T-cell subsets, monocytes/ CD45 isoform
macrophages, granulocytes
CD45RO Memory and activated T cells; B cells, CD45 isoform
monocytes/macrophages
CD46 Hematopoietic cells Membrane cofactor protein (MCP); binds to C3b and C4b and regulates complement
pathway
CD47R Leukocytes; endothelium Integrin-associated protein (IAP); leukocyte migration, extravasation, and activation
CD48 Leukocytes (not neutrophils) Binds CD2; adhesion; costimulation
CD49a–f Various distributions Integrin a1-6 chain; binds to CD29 to form VLA-1 to VLA-6; binds extracellular matrix
components such as fibronectin, laminin, collagen (CD49D binds VCAM-1, fibronectin,
MAdCAM-1, invasin); lymphocyte homing; extracellular adhesion; embryonic development
CD50 Thymocytes, B cells, T cells, ICAM-3; adhesion
monocytes, granulocytes
CD51 Platelets/megakaryocytes, Integrin α-chain; associates with CD61; binds vitronectin, fibronectin, fibrinogen; extracellular
granulocytes, monocytes, T cells adhesion; T-cell costimulation; epithelial inflammatory response
CD52 Leukocytes GPI linked, signaling, defined by CAMPATH-1
CD54 Broad distribution; increased on ICAM-1; binds LFA-1; adhesion; leukocyte transendothelial migration, rhinovirus receptor
activated leukocytes
CD55 Hematopoietic cells and some Decay accelerating factor (DAF); binds complement fragment C3b; regulation of complement
nonhematopoietic cells activation
CD56 NK cells, NK-T cells NKH-1; adhesion
CD57 NK cells, T-cell subset, B cells, Oligosaccharide expressed on cell surface glycoproteins
monocytes
CD58 Hematopoietic cells and non- LFA-3; binds CD2; adhesion; lymphocyte coactivation
hematopoietic cells
CD59 Hematopoietic cells and non- Binds complement components C8 and C9 and regulates assembly of complement
hematopoietic cells membrane attack complex
CD61 Platelets/megakaryocytes, Integrin β 3 subunit; associates with CD41 or CD51
macrophages
CD62E Endothelium ELAM-1 or E-selection; binds sialyl-Lewis X; adhesion; mediates rolling interaction of
neutrophils on endothelium and neutrophil extravasation
CD62L B cells, T cells, monocytes, NK cells LECAM-1, LAM-1 (or L-selectin); binds CD34 and GlyCAM; adhesion; mediates rolling
interactions with endothelium and call extravasation
CD62P Platelets/megakaryocytes, endothelium P-selectin; binds sialyl-Lewis X; mediates interaction of platelets with neutrophils and
monocytes; mediates rolling interaction of neutrophils with endothelium
CD64 Monocytes/macrophages, mature FcγR1 (high-affinity IgG receptor)
neutrophils
CD65 Neutrophils, eosinophils, basophils During myeloid differentiation it appears after myeloperoxidase, appears to be the ligand for
monocyte subset, CD56 bright NK CD62L
cells
CD66c Differentiating myeloid cells peaks at Member of the carcinoeEDryonic antigen (CEA) family
promyelocyte stage, subpopulation of
monocytes
CD68 Monocytes/macrophages Macrosialin; early activation antigen; role in phagocytic activity
CD69 Activated T cells, B cells, macrophages, Early activation antigen; costimulation
NK cells
CD70 Activated B cells and T cells; Binds to CD27; costimulation
macrophages
CD71 Activated leukocytes, erythroid Transferrin receptor; cell activation
precursors
CD72 B cells Ligand for CD5; B-cell activation and differentiation; costimulation