Page 1354 - Clinical Immunology_ Principles and Practice ( PDFDrive )

1314 APPENDIX 1 Selected CD Molecules and Their Characteristics

CD Molecule Predominant Distribution Identity/Function
CD134 Activated T cells OX-40 antigen of TNFR superfamily (binds OX-40 ligand); T-cell–B-cell interaction and T-cell
costimulation
CD135 Lymphoid and myeloid cell progenitor Flt3 ligand receptor; development of myeloid and lymphoid progenitors
subsets
CD137 Activated T cells 4-1BB; binds 4-1BB ligand and extracellular matrix components; T-cell–B-cell interaction and
T-cell costimulation; extracellular adhesion; signal transduction
CD138 B-cell subset, plasma cells, epithelial Syndecan-1; binds interstitial matrix proteins; B cell–matrix interactions
cells
CD140a,b Endothelial cells PDGF receptor α and β chain; embryonic development; signal transduction; chemotaxis
CD141 Endothelium Thrombomodulin (binds thrombin); regulates coagulation
CD142 Endothelium Tissue factor; binds plasma factors VII/VIIa; hemostasis, coagulation, and angiogenesis
CD143 Endothelium Angiotensin-converting enzyme (ACE); binds angiotensin 1; regulates blood pressure
CD144 Endothelium VE-cadherin; cell–cell adhesion; maintenance of endothelium integrity
CD146 Activated T-cell subset Mel-CAM, adhesion molecule during development
CD150 T-cell and B-cell subsets Surface lymphocyte activation marker (SLAM); B cell–T cell interaction; costimulation
CD151 Not defined PETA-3; regulates platelet aggregation and mediator release
CD152 Activated T cells CTLA-4; binds B7-1 (CD80) and B7-2 (CD86); T-cell costimulation–negative signal
CD153 T cells CD30 ligand; T-cell activation, differentiation, and regulation
CD154 Activated T cells CD40 ligand; T-cell costimulation
CD156a Leukocytes, B cells Transmembrane glycoprotein; disintegrin and metalloproteinase domain (ADAM) family
member; leukocyte adhesion and protease function; infiltration of myelomonocytic cells
CD156b Broad distribution TNF-α-converting enzyme (TACE); disintegrin and metalloproteinase domain (ADAM) family
member; cleaves TNF and transforming growth factor-α from cell surface, thereby
releasing soluble form
CD158 NK cells Killer immunoglobulin-like receptors (KIR); family of molecules that inhibit NK cytotoxic
activity
CD159a NK cells NKG2A (killer cell lectin-like receptor)
CD161 NK cells Natural killer cell receptor-P1; target cell recognition; NK cell activation
CD162 Granulocyte and T-cell subsets P-selectin glycoprotein ligand-1 (PSGL-1); adhesion
CD166 Activated T cells, B cells ALCAM; binds CD6; T-cell activation; thymocyte development
CD167a Epithelial cells Discoidin domain receptor 1 (DDD1); tyrosine kinase receptor; binds to collagen; cell–cell
contact and adhesion
CD178 Activated T cells; various tissue cells FAS ligand (ligand for CD95); binding to FAS triggers apoptosis
CD179a Pro-B and pre-B cells VpreB; forms surrogate light chain with CD179b; early B-cell differentiation
CD179b Pro-B and pre-B cells λ5; forms surrogate light chain with CD179a; early B-cell differentiation
CD180 B cells RP105; toll-like receptor family; regulates B-cell recognition and signaling of LPS
CD183 Effector/memory T cells, NK cells, CXCR3 receptor for interferon-inducible chemokines IP10, Mig, and I-TAC; chemotactic
eosinophils migration of effector T cells into areas of inflammation
CD184 Leukocytes; hematopoietic progenitors CXCR4 receptor for chemokines such as stromal cell-derived factor 1 (SDF-1) (fusin);
chemotaxis; HIV-1 coreceptor
CD195 Broad distribution; myeloid cells, CCR5 receptor for chemokines such as macrophage inflammatory proteins, MIP-1a and
lymphocytes, T lymphocytes, MIP-1b, and RANTES; chemotaxis; HIV-1 coreceptor
neurons, epithelium, endothelium
CDw197 Lymphoid tissues, B cells, T-cell CCR7 chemokine receptor; chemotaxis; T-cell homing and migration
subset
CD201 Endothelial cells Protein C receptor; coagulation
CD203c Mast cells, basophils Member of the ectonucleotide pyrophosphatase/phosphodiesterase enzymes
CD204 Myeloid cells, monocytes/macrophages Macrophage scavenger receptor-1 (MSR1); mediates binding, internalization, and processing
of various negatively charged macromolecules
CD206 Dendritic cells, macrophages, myeloid Mannose receptor, C-type 1; binds microorganisms; phagocytosis
cells, endothelial cells
CD207 Dendritic cells, Langerhans cells Langerin; mannose receptor; phagocytosis and internalization of antigen for processing
CD208 Dendritic cells DC-LAMP
CD209 Dendritic cells DC-SIGN
CDw210 Broad distribution I1-10 receptor α and β chain
CD212 T cells, NK cells IL-12 receptor β 1 chain
CD213a1,a2 Lymphocytes, bronchial epithelial and IL-13 receptor α 1 and α 2 chains
smooth muscle cells
CDw217 Activated T-cell subset IL-17; cytotoxic T-lymphocyte–associated serine esterase 8; stimulates cell activation;
induces osteoclast differentiation factor (ODF)
CD220 Broad distribution Insulin receptor; stimulates glucose uptake
CD molecule Predominant distribution Identity/function
CD221 Broad distribution Insulin-like growth factor 1 receptor; cell signaling; activation, and differentiation
CD222 Broad distribution Mannose-6-phosphate receptor; insulin-like growth factor 2 receptor
CD226 NK cells, platelets, monocytes, T-cell Platelet and T-cell activation antigen 1 (PTA1); adhesion
subset
CD233–241 Erythrocytes Various erythrocyte membrane antigens, including blood group–associated glycoproteins