Page 355 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 18 ■ Disorders of Granulocytes and Monocytes 339

Chronic Benign Neutropenia Monocytopenia

C N k

mm , m .

k -

. F m NOTE: This is a good time to review the de nitions of the Key

m m m J Terms in the Glossary and ash cards on . Also,

Y m , A , W E . B m - a good time to complete Review Questions related to the

m m preceding content.

. N k

m m , m z ,

k .
MORPHOLOGICAL ABNORMALI IES OF

Eosinopenia MA URE GRANULOCY ES

T , - m A m m m

. E q m m , ,

m - m ( . ).

m mm .

Nuclear Abnormalities
Basopenia

T m m , - Hypersegm entation

, m m - Hypersegmentation m q m

. P x m . m m

TABLE 18.2 Comparative Morphological Characteristics of Granulocyte Abnormalities

Classi cation Name of Abnormality Major Characteristic Associated Condition

Nuclear Hypersegmentation Segmented neutrophils with >5 lobes De ciencies of vitamin B or folic
12
Abnormality or nuclear segments acid with abnormally enlarged, oval-

shaped erythrocytes

Pseudohypersegmentation may be

seen in old segmented neutrophils.

Pelger-Huët anomaly Mature neutrophils with heavy Abnormal nucleic acid metabolism,

chromatin clumping. although the speci c abnormality is

unknown.

Nuclear shape may resemble a Function of the cells are considered

dumbbell (pince-nez form) or a to be normal.
pair of eyeglasses.

Pyknotic nucleus A condensation of a neutrophil Artifact of EDTA anticoagulated blood

nucleus that has been stored for ____ hours.

Distinguish from similar-looking

nucleated red blood cells, e.g.,

metarubricyte or normoblast.

Cytoplasmic Toxic granulation Prominent dark granulation, May represent the precipitation of

Abnormality either ne or heavy, can be observed ribosomal protein (RNA) caused by

in band and segmented neutrophils or metabolic toxicity within the cells

monocytes.

Most frequently associated with
infectious states. It may be seen in

conditions such as burns and malig-
nant disorders or as the result of drug.

(continued)