Page 107 - Textbook of Pathology, 6th Edition
P. 107
91 CHAPTER 4
Figure 4.16 Amyloidosis spleen. A, The pink acellular amyloid material is seen in the red pulp causing atrophy of while pulp. B, Congo red
staining shows Congophilia as seen by red-pink colour. C, When viewed under polarising microscopy the corresponding area shows apple-green Immunopathology Including Amyloidosis
birefringence.
Later, as the deposits increases, they compress the However, hepatic function remains normal even at an
cords of hepatocytes so that eventually the liver cells advanced stage of the disease.
are shrunken and atrophic and replaced by amyloid. To a lesser extent, portal tracts and Kupffer cells are
involved in amyloidosis.
Figure 4.17 Amyloidosis of the liver. A, The deposition is extensive
in the space of Disse causing compression and pressure atrophy of
hepatocytes. B, Congo red staining shows congophilia which under
polarising microscopy. C, shows apple-green birefringence.
