Page 47 - Textbook of Pathology, 6th Edition
P. 47

31  CHAPTER 3







































                                                                                                                      Cell Injury and Cellular Adaptations
































           Figure 3.7  Ultrastructural changes during cell injury due to hypoxia-ischaemia.



              While cell damage from oxygen deprivation by above  Ischaemia-Reperfusion Injury and
           mechanisms develops slowly, taking several minutes to  Free Radical-Mediated Cell Injury
           hours, the cell injury is accentuated after restoration of blood  Depending upon the duration of ischaemia/hypoxia,
           supply and subsequent events termed ischaemic-reperfusion  restoration of blood flow may result in the following
           injury and liberation of toxic free radicals, discussed below.  3 different consequences:
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