Page 52 - Textbook of Pathology, 6th Edition

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SECTION I

Figure 3.12 Intracellular hyaline as Russell’s bodies in the plasma
cells. The cytoplasm shows pink homogeneous globular material due to
accumulated immunoglobulins. Figure 3.13 Extracellular hyaline deposit in leiomyoma uterus. The
centres of whorls of smooth muscle and connective tissue show pink
homogeneous hyaline material (connective tissue hyaline).
are stained by alcian blue. However, epithelial mucin stains
positively with periodic acid-Schiff (PAS), while connective CONNECTIVE TISSUE MUCIN. A few examples of
tissue mucin is PAS negative but is stained positively with disturbances of connective tissue mucin are as under:
colloidal iron. 1. Mucoid or myxoid degeneration in some tumours e.g.
myxomas, neurofibromas, fibroadenoma, soft tissue
EPITHELIAL MUCIN. Following are some examples of sarcomas etc (Fig. 3.15) .
functional excess of epithelial mucin: 2. Dissecting aneurysm of the aorta due to Erdheim’s medial
1. Catarrhal inflammation of mucous membrane (e.g. of degeneration and Marfan’s syndrome.
General Pathology and Basic Techniques
respiratory tract, alimentary tract, uterus). 3. Myxomatous change in the dermis in myxoedema.
2. Obstruction of duct leading to mucocele in the oral cavity 4. Myxoid change in the synovium in ganglion on the wrist.
and gallbladder.
3. Cystic fibrosis of the pancreas. SUBCELLULAR ALTERATIONS IN CELL INJURY
4. Mucin-secreting tumours (e.g. of ovary, stomach, large Certain morphologically distinct alterations at subcellular
bowel etc) (Fig. 3.14) . level are noticeable in both acute and chronic forms of cell

Figure 3.14 Epithelial mucin. Mucinous cystadenoma of the ovary Figure 3.15 Connective tissue mucin (myxoid change) in
showing intracytoplasmic mucinous material in the epithelial cells lining neurofibroma.
the cyst.